KL

Gene Symbol KL
Entrez Gene 9365
Alt Symbol -
Species Human
Gene Type protein-coding
Description klotho
Other Description -
Swissprots Q96KV5 Q9UEI9 Q5VZ95 Q96KW5 Q9UEF7 Q9Y4F0
Accessions BAA24940 BAA24941 BAL03067 CAC94767 CAC94773 CAR95139 EAX08525 EAX08526 Q9UEF7 AA890465 AB005142 BAA23382 AK097349 BAG53456 CB988086 XM_006719895 XP_006719958 NM_004795 NP_004786 NM_153683
Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). {ECO:0000250}.
Subcellular Location Klotho peptide: Secreted.
Tissue Specificity Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney. {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:11043382, ECO:0000269|PubMed:11162628, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:9464267}.
Top Pathways Endocrine and other factor-regulated calcium reabsorption, Pentose and glucuronate interconversions, Starch and sucrose metabolism

Human KL / Klotho ELISA Kit (Sandwich ELISA) - LS-F6629 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 6.5 pg/ml
Range 3.12-200 pg/ml

Mouse KL / Klotho ELISA Kit (Sandwich ELISA) - LS-F6578 from LifeSpan Bioscience

Category ELISA Kit
Prices $740.00
Sizes 1 plate
Sensitivity 3.12 pg/ml
Range 3.12-200 pg/ml

Rat KL / Klotho ELISA Kit (Sandwich ELISA) - LS-F7191 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.156 ng/ml
Range 3.12-200 pg/ml

Mouse KL / Klotho ELISA Kit (Sandwich ELISA) - LS-F11896 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 15.6
Range 3.12-200 pg/ml

Human KL / Klotho ELISA Kit (Sandwich ELISA) - LS-F11895 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 7.8 pg/ml
Range 3.12-200 pg/ml

Rat KL / Klotho ELISA Kit (Sandwich ELISA) - LS-F11897 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 78
Range 3.12-200 pg/ml

Human Klotho DuoSet ELISA - DY5334-05 from R&D Systems

Category ELISA Kit
Prices $299.00
Sizes 1 kit (for 5 Plates)
Range 78.10 - 5,000 pg/mL

Human Klotho ELISA Kit - abx051325 from Abbexa

Category ELISA Kit

Human Klotho ELISA Kit - abx152140 from Abbexa

Category ELISA Kit
Sensitivity 0.057 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Klotho (KL), Human, ELISA Kit - SEH757Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.058ng/mL
Range 0.156-10ng/mL

Klotho, Human, ELISA Kit - CSB-E13235h from ARP American Research Products

Category ELISA Kit
Prices $550.00, $790.00, $791.00, $794.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 0.039 ng/ml
Range 0.156 ng/ml-10 ng/ml

Klotho, Human, ELISA Kit - E01K0027 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t
Sensitivity 0.1ng/ml
Range 0.5-10ng/mL,

Klotho, KL, Human, ELISA Kit - E2253h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 7.8-500 pg/mL

Klotho (KL), Human, CLIA Kit - SCH757Hu from ARP American Research Products

Category CLIA Kit
Prices $840.00
Sizes 96 t
Sensitivity 0.047ng/mL
Range 0.156-10ng/mL

Human KL ELISA Kit - HK0034 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Klotho - MBS007545 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00
Sizes 48 strip wells, 96 strip wells

Klotho, ELISA Kit - MBS741754 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Klotho, ELISA Kit - MBS737428 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

klotho, ELISA Kit - MBS702872 from MyBioSource

Category ELISA Kit
Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human Klotho is typically less than 0.039 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 0.156 ng/ml -10 ng/ml.

Klotho, ELISA Kit - MBS734114 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Klotho, ELISA Kit - MBS010147 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 pg/ml.
Range 1.56 pg/ml ~ 50 pg/ml.

Klotho, ELISA Kit - MBS035503 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Klotho, ELISA Kit - MBS020147 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Klotho, ELISA Kit - MBS044986 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Klotho, ELISA Kit - MBS2516159 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 4.688pg/mL
Range 7.813-500pg/mL
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