GCK

Gene Symbol	GCK
Entrez Gene	2645
Alt Symbol	FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Species	Human
Gene Type	protein-coding
Description	glucokinase (hexokinase 4)
Other Description	ATP:D-hexose 6-phosphotransferase|HK IV|glucokinase|hexokinase D, pancreatic isozyme|hexokinase type IV|hexokinase-4|hexokinase-D
Swissprots	A4D2J2 A4D2J3 Q05810 P35557
Accessions	AAA67541 AAA67542 AAB97680 AAB97681 AAB97682 AGA96145 AGH08211 AGH08212 AGH08213 AGH08214 AGH08215 AGH08216 AGH08217 AGH08218 AGH08220 AGH08221 AGH08222 AGH08223 CBF63115 CBU87991 EAL23764 EAL23765 EAL23766 EAW61114 EAW61115 EAW61116 P35557 AK122876 BAG53774 BC001890 AAH01890 BT007062 AAP35711 CD251038 DA640823 DQ893835 ABM84761 EU008605 ABS31137 M69051 AAB59563 M88011 AAA51824 M90299 AAA52562 NM_000162 NP_000153 NM_033507 NP_277042 NM_033508 NP_277043
Function	Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Specificity	Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
Top Pathways	Glucagon signaling pathway, Central carbon metabolism in cancer, Insulin signaling pathway, Prolactin signaling pathway, Glycolysis / Gluconeogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human GLK full length protein - ab123840 from Abcam Category Protein Prices $192.00 Sizes 10 µg Source E. coli Species Human

Active human GLK full length protein - ab82193 from Abcam Category Protein Prices $275.00 Sizes 10 µg Source E. coli Species Human

Active human GLK protein - ab177265 from Abcam Category Protein Prices $483.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

E. coli GLK full length protein - ab183231 from Abcam Category Protein Prices $301.00 Sizes 100 µg Source E. coli Species Escherichia coli

GLK full length protein - ab82190 from Abcam Category Protein Prices $270.00 Sizes 10 µg Source E. coli

GLK peptide - ab108095 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human GLK full length protein - ab85977 from Abcam Category Protein Source E. coli Species Human

Human GLK full length protein - ab82191 from Abcam Category Protein Source E. coli Species Human

Human GLK full length protein - ab73514 from Abcam Category Protein Source E. coli Species Human

Human GLK peptide - ab101298 from Abcam Category Peptide

GCK / Germinal Center Kinase Antibody Blocking Peptide - LS-E1597 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCK / Germinal Center Kinase Antibody Blocking Peptide - LS-E3755 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCK / Germinal Center Kinase Antibody Blocking Peptide - LS-E8653 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCK / Germinal Center Kinase Antibody Blocking Peptide - LS-E17582 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCK / Glucokinase Antibody Blocking Peptide - LS-E22475 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCK / Glucokinase Antibody Blocking Peptide - LS-E9359 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCK / Glucokinase Antibody Blocking Peptide - LS-E9360 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GK / Glycerol Kinase Antibody Blocking Peptide - LS-E2045 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GK / Glycerol Kinase Antibody Blocking Peptide - LS-E20258 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Glycerol Kinase Blocking Peptide - NBP1-57033PEP from Novus Biologicals Category Peptide Prices $169.00 Sizes 100 µg Species Human

Glucokinase/GCK Partial Recombinant Protein - H00002645-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Glucokinase/GCK Recombinant Protein - H00002645-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Glycerol Kinase Partial Recombinant Protein - H00002710-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Glycerol Kinase Recombinant Protein - H00002710-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human Glucokinase/GCK Protein - NBP1-99787 from Novus Biologicals Category Protein Prices $145.00 Sizes 10 µg Source E. coli. Species Human

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