DYRK2

Gene Symbol DYRK2
Entrez Gene 8445
Alt Symbol -
Species Human
Gene Type protein-coding
Description dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
Other Description dual specificity tyrosine-phosphorylation-regulated kinase 2
Swissprots B2R9V9 Q9BRB5 Q92630
Accessions CCQ43222 EAW97176 EAW97177 Q92630 AK024870 AK025018 AK313937 BAG36656 BC005809 AAH05809 BC006375 AAH06375 CN303286 DA768075 DB461362 JF432719 ADZ15936 Y09216 CAA70418 Y13493 CAA73885 NM_003583 NP_003574 NM_006482 NP_006473
Function Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser- 641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required
Subcellular Location Cytoplasm. Nucleus. Note=Translocates into the nucleus following DNA damage.
Tissue Specificity Testis, after the onset of spermatogenesis. {ECO:0000269|PubMed:9748265}.

DYRK2 (D9A3K) Rabbit mAb - 11921 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D9A3K
Western blot analysis of extracts from various cell lines using DYRK2 (D9A3K) Rabbit mAb.

DYRK2 Antibody - 8143 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using DYRK2 Antibody.

Dyrk2 (H-80) - sc-66867 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dyrk2 (H-80): sc-66867. Western blot analysis of Dyrk2 expression in non-transfected 293T: sc-117752 (A), human Dyrk2 transfected 293T: sc-158464 (B), K-562 (C), PC-3 (D) and SK-MEL-28 (E) whole cell lysates.

Dyrk2 (C-20) - sc-18951 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dyrk2 (C-20): sc-18951. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic and membrane staining of cells in seminiferous ducts.

Dyrk2 (S-23) - sc-130743 from Santa Cruz Biotechnology

Host Rabbit
Clonality Polyclonal
Dyrk2 (S-23): sc-130743. Western blot analysis of Dyrk2 expression in 293 whole cell lysate.

Dyrk2 (K-15) - sc-31974 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dyrk2 (K-15): sc-31974. Western blot analysis of Dyrk2 expression in Jurkat (A) and SK-MEL-28 (B) whole cell lysates.

Dyrk2 (T-16) - sc-31972 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dyrk2 (T-16): sc-31972. Immunofluorescence staining of formalin-fixed HepG2 cells showing cytoplasmic and nuclear localization.

Anti-DYRK2 antibody - ab37912 from Abcam

Prices $379.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DYRK2 antibody (ab37912) at 1/100 dilution + HEK 293 cell lysate.

Anti-DYRK2 antibody - ab116674 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DYRK2 antibody (ab116674) at 1/100 dilution + K562 cell line lysate at 35 µg

Anti-DYRK2 antibody - ab56363 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56363 DYRK2 antibody at 1ug/ml.

Anti-DYRK2 Antibody (aa1-107) - LS-C143827 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DYRK2 Antibody (aa410-423) - LS-C148930 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (aa520-549, Biotin) - LS-C256401 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (aa520-549, APC) - LS-C256400 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (aa520-549, AP) - LS-C256398 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (aa520-549, FITC) - LS-C256402 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (aa520-549, PE) - LS-C256404 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (aa520-549, Azide-free, HRP) - LS-C256403 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (N-Terminus, AP) - LS-C276953 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (aa401-450) - LS-C151684 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DYRK2 antibody Western Blot of Fetal Lung.

Anti-DYRK2 Antibody (N-Terminus, FITC) - LS-C276957 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (N-Terminus, APC) - LS-C276955 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (Internal) - LS-C141945 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of DYRK2 in 293 whole cell lysates.

Anti-DYRK2 Antibody (N-Terminus, Biotin) - LS-C276956 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DYRK2 Antibody (N-Terminus, Azide-free, HRP) - LS-C276958 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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