| Gene Symbol | CDKN2C |
|---|---|
| Entrez Gene | 1031 |
| Alt Symbol | INK4C, p18, p18-INK4C |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) |
| Other Description | CDK6 inhibitor p18|cyclin-dependent inhibitor|cyclin-dependent kinase 4 inhibitor C|cyclin-dependent kinase 6 inhibitor p18|p18-INK6 |
| Swissprots | Q8TB83 P42773 |
| Accessions | AAC39783 AAF28398 AAM11873 CBX47327 EAX06833 EAX06834 EAX06835 EAX06836 P42773 AF041248 AAC39782 AK021794 AK091170 BAG52297 BC000598 AAH00598 BC005041 AAH05041 BC016173 AAH16173 BC017036 BE783451 BE831176 CR450289 CAG29285 DQ891516 ABM82442 DQ894707 ABM85633 U17074 AAC50074 NM_001262 NP_001253 NM_078626 NP_523240 |
| Function | Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. |
| Tissue Specificity | Highest levels found in skeletal muscle. Also found in pancreas and heart. |
| Top Pathways | Cell cycle, HTLV-I infection, Transcriptional misregulation in cancer |