GRIA3
| Gene Symbol | GRIA3 |
|---|---|
| Entrez Gene | 2892 |
| Alt Symbol | GLUR-C, GLUR-K3, GLUR3, GLURC, GluA3, MRX94 |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamate receptor, ionotropic, AMPA 3 |
| Other Description | AMPA-selective glutamate receptor 3|dJ1171F9.1|gluR-3|glutamate receptor 3|glutamate receptor C|glutamate receptor subunit 3|glutamate receptor, ionotrophic, AMPA 3 |
| Swissprots | Q9HDA1 Q4VXD5 D3DTF1 Q9P0H1 Q9HDA2 Q4VXD6 P42263 Q9HDA0 |
| Accessions | AAF23961 AAF61847 AAF61848 AAF97857 AAF97858 AAF97859 EAX11865 EAX11866 EAX11867 P42263 AK297136 BAH12506 AW166130 BC032004 AAH32004 BC117464 AAI17465 BE504553 BY799542 DA158269 DA179917 DA180344 DA191279 DB505790 HQ258659 ADR83410 U10301 AAA67922 U10302 AAA67923 NM_000828 NP_000819 NM_001256743 NP_001243672 NM_007325 NP_015564 NM_181894 |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. {ECO:0000269|PubMed:21172611}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Note=Interaction with CNIH2 and CNIH3 promotes cell surface expression. {ECO:0000250}. |
| Top Pathways | cAMP signaling pathway, Circadian entrainment, Retrograde endocannabinoid signaling, Nicotine addiction, Amphetamine addiction |
GluR-3 CRISPR/Cas9 KO Plasmid (h) - sc-403848 from Santa Cruz Biotechnology
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GluR-3 HDR Plasmid (h) - sc-403848-HDR from Santa Cruz Biotechnology
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GluR-3 Double Nickase Plasmid (h) - sc-403848-NIC from Santa Cruz Biotechnology
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GluR-3 Double Nickase Plasmid (h2) - sc-403848-NIC-2 from Santa Cruz Biotechnology
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GluR-3 CRISPR Activation Plasmid (h) - sc-403848-ACT from Santa Cruz Biotechnology
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GluR-3 CRISPR Activation Plasmid (h2) - sc-403848-ACT-2 from Santa Cruz Biotechnology
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GluR-3 Lentiviral Activation Particles (h) - sc-403848-LAC from Santa Cruz Biotechnology
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GluR-3 Lentiviral Activation Particles (h2) - sc-403848-LAC-2 from Santa Cruz Biotechnology
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GluR-3 siRNA (h) - sc-35489 from Santa Cruz Biotechnology
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GluR-3 shRNA Plasmid (h) - sc-35489-SH from Santa Cruz Biotechnology
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GluR-3 shRNA (h) Lentiviral Particles - sc-35489-V from Santa Cruz Biotechnology
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Glutamate Receptor 3 RNAi - H00002892-R02 from Novus Biologicals
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Glutamate Receptor 3 RNAi - H00002892-R03 from Novus Biologicals
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MISSION® esiRNA - EHU157101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2372 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2372 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11268 from Sigma-Aldrich
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GRIA3 siRNA (Human) - CRH1946 from Cohesion Biosciences
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Glutamate Receptor 3 RNAi - H00002892-R01 from Novus Biologicals
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GRIA3 - MBS8228305 from MyBioSource
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shRNA set against Human GRIA3 (NM_000828.4) - SHH307754 from Creative biogene
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shRNA set against Human GRIA3(NM_000828.4) - SHH103943 from Creative biogene
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shRNA set against Human GRIA3(NM_007325.4) - SHH103975 from Creative biogene
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Human GRIA3 siRNA - orb262448 from Biorbyt
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GRIA3 shRNA Plasmid (Human) - CHH1946 from Cohesion Biosciences
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