POLR3D

Gene Symbol POLR3D
Entrez Gene 661
Alt Symbol BN51T, RPC4, RPC53, TSBN51
Species Human
Gene Type protein-coding
Description polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
Other Description BN51 (BHK21) temperature sensitivity complementing|DNA-directed RNA polymerase III 47 kDa polypeptide|DNA-directed RNA polymerase III subunit D|DNA-directed RNA polymerase III subunit RPC4|RNA polymerase III 47 kDa subunit|RNA polymerase III subunit C4|RPC53 homolog|temperature sensitive complementation, cell cycle specific, tsBN51
Swissprots Q9BPV7 Q9BXB3 Q6FI28 P05423 Q9BPZ1
Accessions AAA72377 AAD29429 EAW63689 EAW63690 EAW63691 EAW63692 P05423 AF346574 AAK15371 AK026588 AK125346 AK295725 BAG58566 AY092086 AAM18216 BC000516 BC002603 AAH02603 BC003039 BC004484 AAH04484 BQ006609 BX537545 CR536509 CAG38747 CR541803 CAG46602 HQ447310 ADQ31797 M17754 AAA51838 XM_011544629 XP_011542931 XR_949463 NM_001722 NP_001713
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). {ECO:0000250}.
Subcellular Location Nucleus.
Top Pathways Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism

POLR3D CRISPR/Cas9 KO Plasmid (h) - sc-410705 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3D HDR Plasmid (h) - sc-410705-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3D Double Nickase Plasmid (h) - sc-410705-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3D Double Nickase Plasmid (h2) - sc-410705-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3D CRISPR Activation Plasmid (h) - sc-410705-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3D CRISPR Activation Plasmid (h2) - sc-410705-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3D Lentiviral Activation Particles (h) - sc-410705-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3D Lentiviral Activation Particles (h2) - sc-410705-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR3D siRNA (h) - sc-77815 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POLR3D shRNA Plasmid (h) - sc-77815-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POLR3D shRNA (h) Lentiviral Particles - sc-77815-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU080741 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17129 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17129 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05910 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05910

POLR3D siRNA (Human) - CRH0456 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

POLR3D RNAi - H00000661-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human POLR3D (NM_001722.2) - SHH379564 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human POLR3D(NM_001722.2) - SHR128028 from Creative biogene

Category siRNA
Species Reactivities Human

Human POLR3D siRNA - orb260958 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

POLR3D shRNA Plasmid (Human) - CHH0456 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

POLR3D miRNA 3'UTR clone - MiUTR1H-08081 from Creative biogene

Species Reactivities Human
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