Atp5a1
| Gene Symbol | Atp5a1 |
|---|---|
| Entrez Gene | 65262 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle |
| Other Description | ATP synthase subunit alpha, mitochondrial|ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit|mitochondrial H+-ATP synthase alpha subunit |
| Swissprots | Q6P753 P15999 |
| Accessions | EDL84693 EDL84694 EDL84695 EDL84696 EDL84697 EDL84698 EDL84699 EDL84700 EDL84701 EDL84702 P15999 BC061830 AAH61830 FQ214031 FQ214146 FQ225416 FQ225735 FQ227531 FQ227720 J05266 AAA40784 X56133 CAA39599 NM_023093 NP_075581 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). {ECO:0000250}. |
| Subcellular Location | Mitochondrion inner membrane {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Note=Colocalizes with HRG on the cell surface of T-cells. {ECO:0000250}. |
| Tissue Specificity | Expressed in flagella of epididymal sperm. {ECO:0000269|PubMed:19423663}. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |
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