MME

Gene Symbol	MME
Entrez Gene	4311
Alt Symbol	CALLA, CD10, NEP, SFE
Species	Human
Gene Type	protein-coding
Description	membrane metallo-endopeptidase
Other Description	atriopeptidase|common acute lymphocytic leukemia antigen|enkephalinase|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase variant 1|membrane metallo-endopeptidase variant 2|neprilysin|neprilysin-390|neprilysin-411|neutral endopeptidase 24.11|skin fibroblast elastase
Swissprots	D3DNJ9 A8K6U6 Q3MIX4 P08473
Accessions	AAA52294 ACA05913 ACA05914 CCQ42996 EAW78753 EAW78754 EAW78755 EAW78756 EAW78757 EAW78758 P08473 AK291761 BAF84450 AK310664 AL833459 BC101632 AAI01633 BC101658 AAI01659 BC106070 AAI06071 BC143465 AAI43466 BM151602 BP418894 BX647134 DA574242 DB142029 J03779 AAA51915 KC143287 AGE12493 KC143288 AGE12494 X07166 CAA30157 Y00811 CAA68752 XM_006713646 XP_006713709 XM_006713647 XP_006713710 XM_011512855 XP_011511157 XM_011512856 XP_011511158 XM_011512857 XP_011511159 XM_011512858 XP_011511160 NM_000902 NP_000893 NM_007287 NP_009218 NM_007288 NP_009219 NM_007289 NP_009220
Function	Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:2972276}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.
Top Pathways	Hematopoietic cell lineage, Alzheimer's disease, Protein digestion and absorption, Renin-angiotensin system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MME 293T Cell Transient Overexpression Lysate(Denatured) - H00004311-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

MME overexpression lysate - LY400326 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MME overexpression lysate - LY416064 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MME overexpression lysate - LY416065 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MME overexpression lysate - LY416066 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MME overexpression lysate - LY425018 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MME overexpression lysate - LY429337 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MME overexpression lysate - LY429338 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

MME 293 Cell Lysate - 407527 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Neprilysin/CD10 Overexpression Lysate (Denatured) - H00004311-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Neprilysin/CD10 Overexpression Lysate (Native) - NBL1-13148 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

CD10 (h): 293T Lysate - sc-111697 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

MME Over-expression Lysate Product - GWB-831690 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human CD10 / Neprilysin / MME HEK293 Cell Lysate (WB positive control) - 10805-HNCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CD10 / Neprilysin / MME HEK293 Cell Lysate (WB positive control) - 10805-H07HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CD10 / Neprilysin / MME HEK293 Cell Lysate (WB positive control) - 10805-H01HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human CD10 Human Cells Transfected Lysate (positive control) (denatured) - orb173923 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Neprilysin/CD10 Overexpression Lysate (Native) - NBP2-10370 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Neprilysin/CD10 Overexpression Lysate (Native) - NBP2-10369 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Neprilysin/CD10 Overexpression Lysate (Native) - NBP2-11292 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Neprilysin/CD10 Overexpression Lysate (Native) - NBP2-11291 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Neprilysin/CD10 Overexpression Lysate (Native) - NBP2-11165 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Neprilysin/CD10 Overexpression Lysate (Denatured) - H00004311-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human CD10 Human Cells Transfected Lysate (positive control) (denatured) - orb172859 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human CD10 Human Cells Transfected Lysate (positive control) (denatured) - orb172858 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

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