| Gene Symbol |
Med24
|
| Entrez Gene |
23989
|
| Alt Symbol |
911GSE, AU040102, AW547152, D11Ertd307e, DRIP100, Gse2, Pparb2, Pparbp2, R75526, Thrap4, Trap100
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 24
|
| Other Description |
genetic suppressor element 2|mTRAP100|mediator of RNA polymerase II transcription subunit 24|peroxisome proliferation activation receptor binding protein 2|thyroid hormone receptor associated protein 4|thyroid hormone receptor-associated protein 100 kDa|thyroid hormone receptor-associated protein 4|thyroid hormone receptor-associated protein complex 100 kDa component
|
| Swissprots |
Q8R004 Q99K74 Q9D277 A3KFP0 Q9WVF1
|
| Accessions |
EDL16161 EDL16162 EDL16163 Q99K74 AF126543 AAD42776 AF483498 AAL90772 AF483499 AAL90773 AK020269 BAB32051 AK154618 BAE32717 AK158385 AK177922 AK178404 AK184302 AK186427 AK186712 AK191628 AK192144 AK192379 AK193218 AK204361 AK205600 AK206426 AK209354 AK214599 AK219304 AW541655 BC005409 AAH05409 BC078459 BE950589 BU612260 BY034665 CX566267 L27154 XM_006533302 XP_006533365 XM_006533303 XP_006533366 XM_006533304 XP_006533367 XM_006533305 XP_006533368 NM_011869 NP_035999
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for basal and activator-dependent transcription. {ECO:0000250, ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:12093747}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in the adrenal gland, brain, epididymis, heart, kidney, liver, ovary, pancreas, prostate, skeletal muscle, small intestine, spleen, stomach, testis and thymus. {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:12093747}.
|