| Gene Symbol |
Aox3
|
| Entrez Gene |
71724
|
| Alt Symbol |
1200011D03Rik, AI326299, Aoh1, Aoh2
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
aldehyde oxidase 3
|
| Other Description |
aldehyde oxidase 1|aldehyde oxidase homolog 1|aldehyde oxidase structural homolog 2|azaheterocycle hydroxylase 3
|
| Swissprots |
B2RSI5 G3X982 Q8VI15
|
| Accessions |
AAL36596 AAQ24539 AAQ24540 EDL00068 EDL00069 G3X982 AF172276 AAD51028 AK004700 BAB23485 AK030109 AK050061 AK054065 BAC35643 AK143048 AK149434 AV275739 AY347569 AAQ24537 AY347570 AAQ24538 BB616838 BC024046 BC049853 BC138876 AAI38877 BX633666 XM_006496284 XP_006496347 XM_006496285 XP_006496348 NM_023617 NP_076106
|
| Function |
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:18981221, ECO:0000269|PubMed:21705476, ECO:0000269|PubMed:23019336}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:15383531}.
|
| Tissue Specificity |
Highly expressed in liver (at protein level). In liver, the expression is greater in males than females. {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:15383531, ECO:0000269|PubMed:18981221}.
|
| Top Pathways |
Tyrosine metabolism, Vitamin B6 metabolism, Nicotinate and nicotinamide metabolism, Retinol metabolism, Tryptophan metabolism
|