GLS2

Gene Symbol	GLS2
Entrez Gene	27165
Alt Symbol	GA, GLS, LGA, hLGA
Species	Human
Gene Type	protein-coding
Description	glutaminase 2 (liver, mitochondrial)
Other Description	L-glutamine amidohydrolase|breast cell glutaminase|glutaminase I|glutaminase liver isoform, mitochondrial|phosphate-activated glutaminase|phosphate-dependent glutaminase
Swissprots	B7Z8Q9 Q9NYY2 Q9UI31 Q8IX91 Q9UI32
Accessions	AAO13298 CCO13737 EAW96942 EAW96943 EAW96944 EAW96945 Q9UI32 AF038170 AF110329 AF110330 AAF21933 AF110331 AAF21934 AF223944 AAF33826 AF279698 AAG17701 AI241400 AK000467 AK289471 BAF82160 AK294822 BAG57935 AK303772 BAH14045 BC025661 BC036929 BC048344 BC059370 BC119767 AAI19768 BC119768 AAI19769 BC166649 AAI66649 BI916699 DA060302 DA180204 HM775422 ADR77821 HM775423 ADR77822 HM775424 ADR77823 XM_005268797 XP_005268854 NM_001280796 NP_001267725 NM_001280797 NP_001267726 NM_001280798 NP_001267727 NM_013267 NP_037399 NM_138566
Function	Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000269|PubMed:20378837}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:20378837}.
Tissue Specificity	Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas. {ECO:0000269|PubMed:10620514, ECO:0000269|PubMed:20378837}.
Top Pathways	Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GLS2 peptide - ab169954 from Abcam Category Peptide Prices $176.00 Sizes 50 µg

Human GLS2 protein fragment - ab153287 from Abcam Category Protein Source Wheat germ Species Human

GLS / Glutaminase Antibody Blocking Peptide - LS-E19894 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GLS2 / Glutaminase 2 Antibody Blocking Peptide - LS-E8356 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GLS2 / Glutaminase 2 Antibody Blocking Peptide - LS-E31086 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GLS / Glutaminase Antibody Blocking Peptide - LS-E9792 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GLS2 Protein - H00027165-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Glutaminase Partial Recombinant Protein - H00002744-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GLS2 Blocking Peptide - NBP1-76544PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Bacterial Glutaminase Protein - NBP1-72301 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli

GLS2-Antibody-C-term-E513-Blocking-peptide - BP6650d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GLS2-Antibody-C-term-R471-Blocking-Peptide - BP6650b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GLS Blocking Peptide - 33R-9711 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GLS2 Blocking Peptide - 33R-3113 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Glutaminase liver isoform - H00027165-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Glutaminase liver isoform - H00027165-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Glutaminase liver isoform control peptide - AP26111CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

GLS2 Peptide - 6217P from ProSci Category Peptide Species Human

GLS2 fusion protein - Ag14003 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human GLS2, GST-tagged - GLS2-13316H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Glutaminase 2 (GLS2) - RPJ025Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Glutaminase 2 (GLS2) - RPJ025Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Human Glutaminase liver isoform, mitochondrial(GLS2) - CSB-YP887058HU CSB-EP887058HU CSB-BP887058HU CSB-MP887058HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

GLS fusion protein - Ag24227 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

Glutaminase liver isoform (N-term HIS tag) - TP760217 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

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