| Gene Symbol |
Ptafr
|
| Entrez Gene |
19204
|
| Alt Symbol |
PAFR
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
platelet-activating factor receptor
|
| Other Description |
PAF receptor|PAF-R
|
| Swissprots |
Q8C017 Q62035 B1B170
|
| Accessions |
BAA09468 Q62035 AF004858 AAC53357 AK032547 BAC27919 BC160361 AAI60361 NM_001081211 NP_001074680
|
| Function |
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Found in a range of organs. Expressed most strongly in spleen, followed by skeletal muscle, lung and small intestine. Expressed at moderate levels in the heart. Expressed at relatively low levels in the brain, liver and kidney. {ECO:0000269|PubMed:8670084}.
|
| Top Pathways |
Calcium signaling pathway, Staphylococcus aureus infection, Neuroactive ligand-receptor interaction
|