GRM1

Gene Symbol GRM1
Entrez Gene 2911
Alt Symbol GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13
Species Human
Gene Type protein-coding
Description glutamate receptor, metabotropic 1
Other Description metabotropic glutamate receptor 1|protein phosphatase 1, regulatory subunit 85
Swissprots Q13255 F8W805 Q5VTF8 Q5VTF7 Q13256 Q9UGT0 Q9NU10 Q9UGS9 B9EG79 Q14757 Q14758
Accessions EAW47834 EAW47835 Q13255 AB208837 BAD92074 AK308550 BC111844 AAI11845 BC136280 AAI36281 BC143777 BC143779 L76627 AAB05337 L76631 AAB05338 U31215 AAA87843 U31216 AAA87844 XM_011535782 XP_011534084 XM_011535783 XP_011534085 XM_011535784 XP_011534086 NM_001278064 NP_001264993 NM_001278065 NP_001264994 NM_001278066 NP_001264995 NM_001278067 NP_001264996 NM_000838 NP_000829 NM_001114329
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. {ECO:0000269|PubMed:24603153, ECO:0000269|PubMed:7476890}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:24603153}; Multi-pass membrane protein {ECO:0000269|PubMed:24603153}.
Tissue Specificity Detected in brain.
Top Pathways Calcium signaling pathway, Glutamatergic synapse, Long-term depression, Retrograde endocannabinoid signaling, Long-term potentiation