GRM1

Gene Symbol	GRM1
Entrez Gene	2911
Alt Symbol	GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13
Species	Human
Gene Type	protein-coding
Description	glutamate receptor, metabotropic 1
Other Description	metabotropic glutamate receptor 1|protein phosphatase 1, regulatory subunit 85
Swissprots	Q13255 F8W805 Q5VTF8 Q5VTF7 Q13256 Q9UGT0 Q9NU10 Q9UGS9 B9EG79 Q14757 Q14758
Accessions	EAW47834 EAW47835 Q13255 AB208837 BAD92074 AK308550 BC111844 AAI11845 BC136280 AAI36281 BC143777 BC143779 L76627 AAB05337 L76631 AAB05338 U31215 AAA87843 U31216 AAA87844 XM_011535782 XP_011534084 XM_011535783 XP_011534085 XM_011535784 XP_011534086 NM_001278064 NP_001264993 NM_001278065 NP_001264994 NM_001278066 NP_001264995 NM_001278067 NP_001264996 NM_000838 NP_000829 NM_001114329
Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. {ECO:0000269|PubMed:24603153, ECO:0000269|PubMed:7476890}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:24603153}; Multi-pass membrane protein {ECO:0000269|PubMed:24603153}.
Tissue Specificity	Detected in brain.
Top Pathways	Calcium signaling pathway, Glutamatergic synapse, Long-term depression, Retrograde endocannabinoid signaling, Long-term potentiation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

mGluR-1a CRISPR/Cas9 KO Plasmid (h) - sc-401436 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

mGluR-1a HDR Plasmid (h) - sc-401436-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mGluR-1a Double Nickase Plasmid (h) - sc-401436-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mGluR-1a Double Nickase Plasmid (h2) - sc-401436-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mGluR-1a CRISPR Activation Plasmid (h) - sc-401436-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

mGluR-1a CRISPR Activation Plasmid (h2) - sc-401436-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

mGluR-1a Lentiviral Activation Particles (h) - sc-401436-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mGluR-1a Lentiviral Activation Particles (h2) - sc-401436-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

mGluR-1a/b siRNA (h) - sc-61026 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

mGluR-1a/b shRNA Plasmid (h) - sc-61026-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

mGluR-1a/b shRNA (h) Lentiviral Particles - sc-61026-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

mGluR1 RNAi - H00002911-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU087711 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1826 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1826 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11837 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11837

GRM1 siRNA (Human) - CRH1964 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GRM1 - MBS8216371 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Grm1 (NM_000838.3) - SHH308090 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human GRM1(NM_000838.3) - SHH105511 from Creative biogene Category siRNA Species Reactivities Human

GRM1 shRNA Plasmid (Human) - CHH1964 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

GRM1 miRNA 3'UTR clone - MiUTR1H-04290 from Creative biogene Species Reactivities Human

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