| Gene Symbol | REL |
|---|---|
| Entrez Gene | 5966 |
| Alt Symbol | C-Rel |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-rel avian reticuloendotheliosis viral oncogene homolog |
| Other Description | oncogene REL, avian reticuloendotheliosis|proto-oncogene c-Rel |
| Swissprots | Q17RU2 Q04864 Q6LDY0 Q2PNZ7 |
| Accessions | AAA52073 ABC40747 CBX47437 EAX00028 Q04864 AA279919 AK123369 AK303926 BAG64854 BC051005 BC117191 AAI17192 BC143885 AAI43886 BG036646 BX111941 CN414487 HY123671 X75042 CAA52954 XM_011533010 XP_011531312 NM_001291746 NP_001278675 NM_002908 NP_002899 |
| Function | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an in |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Top Pathways | Viral carcinogenesis, Transcriptional misregulation in cancer |