CD247

Gene Symbol CD247
Entrez Gene 919
Alt Symbol CD3-ZETA, CD3H, CD3Q, CD3Z, IMD25, T3Z, TCRZ
Species Human
Gene Type protein-coding
Description CD247 molecule
Other Description CD247 antigen, zeta subunit|CD3Z antigen, zeta polypeptide (TiT3 complex)|CD3zeta chain|T-cell antigen receptor complex, zeta subunit of CD3|T-cell receptor T3 zeta chain|T-cell surface glycoprotein CD3 zeta chain|TCR zeta chain
Swissprots B1AK49 Q8TAX4 Q5VX13 P20963
Accessions A46461 AAB22030 AAB24602 AAY57330 EAW90790 EAW90791 EAW90792 P20963 AF228312 AAF34793 AI420774 AK128376 BAC87407 AK223325 BAD97045 AK313946 BAG36664 AL557555 BC025703 AAH25703 BI819937 DQ893778 ABM84704 EF079882 EF364117 EF364118 EF364119 ABQ28690 EU117371 ABW06577 EU117372 ABW06578 EU117373 ABW06579 EU118788 ABW96174 EU118789 ABW96175 EU118790 ABW96176 EU118791 ABW96177 EU118792 ABW96178 EU118793 ABW96179 EU176191 ABW03642 EU597245 ACC61185 J04132 AAA60394 X55510 X55511 X55512 XM_011510144 XP_011508446 XM_011510145 XP_011508447 NM_000734 NP_000725 NM_198053 NP_932170
Function Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.
Subcellular Location Membrane; Single-pass type I membrane protein.
Top Pathways Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis)

CD3-ζ (6B10.2) - sc-1239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD3-ζ (6B10.2): sc-1239. Immunofluorescence staining of methanol-fixed Jurkat cells showing membrane staining.

CD3-ζ (E-3) - sc-166435 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD3-ζ (E-3): sc-166435. Western blot analysis of CD3-ζ expression in non-transfected: sc-117752 (A) and human CD3-ζ transfected: sc-114150 (B) 293T whole cell lysates.

CD3-ζ (FL-163) - sc-20919 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

CD3-ζ (H146-968) - sc-101411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Hamster
Clonality Monoclonal
CD3-ζ (H146-968): sc-101411. Western blot analysis of CD3-ζ expression in non-transfected: sc-117752 (A) and human CD3-ζ transfected: sc-173169 (B) 293T whole cell lysates.

CD3-ζ (F-3) - sc-166275 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD3-ζ (F-3): sc-166275. Western blot analysis of CD3-ζ expression in non-transfected: sc-117752 (A) and human CD3-ζ transfected: sc-114150 (B) 293T whole cell lysates.

CD3-ζ (C-20) - sc-1124 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CD3-ζ (C-20): sc-1124. Western blot analysis of CD3-ζ expression in non-transfected: sc-117752 (A) and human CD3-ζ transfected: sc-114150 (B) 293T whole cell lysates.

CD3-ζ (3F67) - sc-70617 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD3-ζ (3F67): sc-70617. Western blot analysis of CD3-ζ expression in MOLT-4 whole cell lysate (A) and mouse thymus tissue extract (B).

p-CD3-ζ (C415.9A) - sc-9975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-CD3-ζ (C415.9A) Alexa Fluor 488: sc-9975 AF488. Intracellular FCM analysis of fixed and permeabilized human peripheral blood leukocytes. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3890.

p-CD3-ζ (96.Tyr 111) - sc-135759 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

p-CD3-ζ (81.Tyr 111) - sc-135758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-CD3 zeta (phospho Y142) antibody - ab59175 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD3 zeta (phospho Y142) antibody (ab59175) at 1/500 dilutionLane 1 : Jurkat cells treated with UV (15 mins)Lane 2 : Jurkat cells treated with UV (15 mins) with phosphopeptide

Anti-CD3 zeta (phospho Y142) antibody [EP265(2)Y] - ab68235 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP265(2)Y
All lanes : Anti-CD3 zeta (phospho Y142) antibody [EP265(2)Y] (ab68235) at 1/2000 dilutionLane 1 : Jurkat cell lysates, membrane un-treatedLane 2 : Jurkat cell lysates, membrane treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-CD3 zeta (phospho Y83) antibody [EP776(2)Y] - ab68236 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP776(2)Y
All lanes : Anti-CD3 zeta (phospho Y83) antibody [EP776(2)Y] (ab68236) at 1/10000 dilutionLane 1 : Jurkat cell lysate, untreated.Lane 2 : Jurkat cell lysate, treated with pervanadateLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated Goat anti-rabbit at 1/2000 dilution

Anti-CD3 zeta antibody - ab190728 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CD3 zeta antibody (ab190728) + extracts of Jurkat cell line

Anti-CD3 zeta antibody - ab17061 from Abcam

Prices $378.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
IHC image of ab17061 staining in Human tonsil formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab17061, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-CD3 zeta antibody - ab74273 from Abcam

Prices $378.00
Sizes 1 ml
Host Rabbit
Clonality Polyclonal
Formalin fixed/paraffin embedded human tonsil tissue section, stained with 1/200 ab74273 for 10 minutes at RT.

Anti-CD3 zeta antibody - ab65118 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-CD3 zeta antibody (ab65118) at 1/60 dilution + Ramos cell line lysates at 35 µg/ml

Anti-CD3 zeta antibody - ab200591 from Abcam

Prices $359.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
All lanes : Anti-CD3 zeta antibody (ab200591) at 0.03 µg/mlLane 1 : Human Tonsil lysatesLane 2 : Jurkat lysatesLysates/proteins at 35 µg per lane.developed using the ECL technique

Anti-CD3 zeta antibody [4A12-F6] - ab188850 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 4A12-F6
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human thymus tissue labeling CD3 zeta with ab188850 at 5 µg/ml.

Anti-CD3 zeta antibody [EP286Y] - ab40804 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP286Y
Anti-CD3 zeta antibody [EP286Y] (ab40804) at 1/500 dilution + 10ug Jurkat cell lysate

Anti-CD3 zeta antibody [EP286Y] (Alexa Fluor® 488) - ab197532 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP286Y
ab197532 staining CD3 zeta in K562 cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab197532 at 1/50 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at 2µg/ml (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-CD3 zeta antibody [EP286Y] (Alexa Fluor® 647) - ab197037 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP286Y
ab197037 staining CD3 zeta in Jurkat cells. The cells were fixed with 100% methanol (5 min), permeabilised in 0.1% Triton X-100 for 5 minutes and then blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated with ab197037 at 1/50 dilution (shown in red) overnight at +4°C. Nuclear DNA was labelled in blue with DAPI.Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-CD3 zeta antibody [EP286Y] (HRP) - ab197038 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP286Y
Anti-CD3 zeta antibody [EP286Y] (HRP) (ab197038) at 1/5000 dilution + Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate at 10 µgdeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD3 zeta antibody [G3] - ab11281 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone G3

Anti-CD3 zeta antibody [G3] (Phycoerythrin) - ab33395 from Abcam

Prices $186.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone G3
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