EWSR1

Gene Symbol EWSR1
Entrez Gene 2130
Alt Symbol EWS, bK984G1.4
Species Human
Gene Type protein-coding
Description EWS RNA-binding protein 1
Other Description EWS RNA-binding protein variant 6|Ewing sarcoma breakpoint region 1|Ewings sarcoma EWS-Fli1 (type 1) oncogene|RNA-binding protein EWS
Swissprots Q96FE8 Q96MN4 Q01844 Q96MX4 Q92635 B0QYK1 Q9BWA2 Q5THL0
Accessions AAD15010 BAA31990 CAA51489 CAA69177 CAA70044 CAH33891 EAW59780 EAW59781 EAW59782 EAW59783 EAW59784 EAW59785 EAW59786 EAW59787 Q01844 AI564543 AK026270 AK056309 BAB71145 AK056681 BAB71252 AK096787 AK127624 AK225096 AK225102 AL833489 AW205707 BC000527 AAH00527 BC004817 AAH04817 BC011048 AAH11048 BC072442 AAH72442 BE741903 BM981230 BX648769 CR456490 CAG30376 CU013087 CAK54518 CU013375 CAK54817 CX786322 DA013931 DA051447 DB051511 DB443651 EU327511 ABY40719 JX977847 AGS36504 S62665 AAB27172 X66899 CAA47350 XM_005261389 XP_005261446 XM_005261390 XP_005261447 XM_011529995 XP_011528297 XM_011529996 XP_011528298 XM_011529997 XP_011528299 XM_011529998 XP_011528300 XM_011529999 XP_011528301 XM_011530000 XP_011528302 XM_011530001 XP_011528303 XM_011530002 XP_011528304 NM_001163285 NP_001156757 NM_001163286 NP_001156758 NM_001163287 NP_001156759 NM_005243 NP_005234 NM_013986 NP_053733
Function Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Subcellular Location Nucleus {ECO:0000269|PubMed:16965792}. Cytoplasm {ECO:0000269|PubMed:16965792}. Cell membrane {ECO:0000269|PubMed:16965792}. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.
Tissue Specificity Ubiquitous.
Top Pathways Transcriptional misregulation in cancer

SignalSilence ® EWS siRNA I - 12175 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (3 nmol)
Species Reactivities Human
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® EWS siRNA I (+), or SignalSilence ® EWS siRNA II #12216 (+), using EWS Antibody #11910 (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). The EWS Antibody confirms silencing of EWS expression, while the β-Actin (D6A8) Rabbit mAb is used as a loading control.

SignalSilence ® EWS siRNA II - 12216 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (3 nmol)
Species Reactivities Human
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® EWS siRNA I #12175 (+), or SignalSilence ® EWS siRNA II (+), using EWS Antibody #11910 (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower). The EWS Antibody confirms silencing of EWS expression, while the β-Actin (D6A8) Rabbit mAb is used as a loading control.

EWS CRISPR/Cas9 KO Plasmid (h) - sc-401036 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EWS HDR Plasmid (h) - sc-401036-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EWS Double Nickase Plasmid (h) - sc-401036-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EWS Double Nickase Plasmid (h2) - sc-401036-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EWS CRISPR Activation Plasmid (h) - sc-401036-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EWS CRISPR Activation Plasmid (h2) - sc-401036-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EWS Lentiviral Activation Particles (h) - sc-401036-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EWS Lentiviral Activation Particles (h2) - sc-401036-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EWS siRNA (h) - sc-35347 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EWS shRNA Plasmid (h) - sc-35347-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EWS shRNA (h) Lentiviral Particles - sc-35347-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EWSR1 RNAi - H00002130-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EWSR1 RNAi - H00002130-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU115631 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8028 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8028 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03024 from Sigma-Aldrich

Category miRNA

EWSR1 siRNA (Human) - CRH1481 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EWSR1 - MBS828497 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EWSR1 (NM_005243.3) - SHH287861 from Creative biogene

Category siRNA
Species Reactivities Human

EWSR1 shRNA Plasmid (Human) - CHH1481 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EWSR1 miRNA 3'UTR clone - MiUTR3H-00761 from Creative biogene

Species Reactivities Human

EWSR1 miRNA 3'UTR clone - MiUTR3H-00762 from Creative biogene

Species Reactivities Human
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