HSD11B2

Gene Symbol HSD11B2
Entrez Gene 3291
Alt Symbol AME, AME1, HSD11K, HSD2, SDR9C3
Species Human
Gene Type protein-coding
Description hydroxysteroid (11-beta) dehydrogenase 2
Other Description -HSD11 type II|11-DH2|11-beta-HSD2|11-beta-hydroxysteroid dehydrogenase type 2|11-beta-hydroxysteroid dehydrogenase type II|NAD-dependent 11-beta-hydroxysteroid dehydrogenase|corticosteroid 11-beta-dehydrogenase isozyme 2|short chain dehydrogenase/reductase family 9C member 3
Swissprots Q9UCW8 Q9UC50 Q8N439 Q9UCW6 A7LB28 P80365 Q9UCW5 C5HTY7 Q9UCW7 Q13194 Q96QN8 Q9UC51 Q6P2G9
Accessions AAB48544 AAD14324 AAK91586 ABS29267 ACS13714 EAW83134 P80365 BC036780 AAH36780 BC064536 AAH64536 U14631 AAA91969 U26726 AAC50356 NM_000196 NP_000187
Function Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Subcellular Location Microsome {ECO:0000269|PubMed:17314322}. Endoplasmic reticulum {ECO:0000269|PubMed:17314322}.
Tissue Specificity Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
Top Pathways Steroid hormone biosynthesis, Aldosterone-regulated sodium reabsorption