APC

Gene Symbol	APC
Entrez Gene	324
Alt Symbol	BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
Species	Human
Gene Type	protein-coding
Description	adenomatous polyposis coli
Other Description	adenomatosis polyposis coli tumor suppressor|adenomatous polyposis coli protein|deleted in polyposis 2.5|protein phosphatase 1, regulatory subunit 46
Swissprots	Q15162 P25054 Q93042 Q15163 D3DT03
Accessions	AAB21145 AAT81590 AAW82777 AAX07544 AAX07546 ABL85064 ABL98125 ABL98126 ABQ09217 ABQ09218 ABQ09219 ABQ09220 ABQ57358 ABQ57359 ABQ57360 ABQ57361 ACD11098 ACD11100 P25054 AB210001 BAE06083 AF038181 AI492038 AK289567 BAF82256 AK294544 BAH11802 AK309033 BC034955 BC056268 AAH56268 BC111462 AAI11463 BC111591 AAI11592 BC111930 AAI11931 BE047584 BF112110 BG548363 BM271918 BM713901 BM975470 BP230350 CA313732 DA777787 DA795663 DQ317525 ABC41553 DQ320123 M73548 AAA60353 M74088 AAA03586 S56365 AAD14918 S67787 AAD13997 S67788 AAD13998 S67789 AAD13999 NM_000038 NP_000029 NM_001127510 NP_001120982 NM_001127511 NP_001120983
Function	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. {ECO:0000269|PubMed:10947987, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:20937854}.
Subcellular Location	Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. Note=Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
Tissue Specificity	Expressed in a variety of tissues.
Top Pathways	Wnt signaling pathway, HTLV-I infection, Endometrial cancer, Colorectal cancer, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

APC/Cy5.5® Conjugation Kit - ab102855 from Abcam Prices $225.00, $237.00, $391.00, $553.00 Sizes 100 µg, 30 µg, 300 µg, 1 mg

APC/Cy7® Conjugation Kit - ab102859 from Abcam Prices $225.00, $237.00, $391.00, $553.00 Sizes 100 µg, 30 µg, 300 µg, 1 mg

APC Antibody Blocking Peptide - LS-E6507 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human APC Protein - H00000324-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

APC-Antibody-Center-Blocking-Peptide - BP19274c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human Activated Protein C protein - orb90033 from Biorbyt Category Protein Prices $289.00, $476.00, $2,125.00 Sizes 100 μg, 200 μg, 1 mg Source Chinese Hamster Ovary Cells (CHO)

APC peptide - orb72331 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

APC peptide - orb216920 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Rat, Cat

APC (phospho-Ser2054) Blocking Peptide - abx062250 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey, Pig

APC Blocking Peptide - abx062251 from Abbexa Category Peptide Species Human, Rat, Bovine, Chicken, Pig

Human APC Protein - abx065147 from Abbexa Category Protein Source E.coli Species Human

APC / DP2.5 - H00000324-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

APC / DP2.5 - H00000324-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Adenomatosis Polyposis Coli Protein (APC), Human - 20-8446 from ARP American Research Products Category Protein Prices $479.00 Sizes 50 µg Source E.coli Species Human

APC Peptide - 350494 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human APC, His-tagged - APC-27359TH from Creative Biomart Category Protein Source E. coli

Recombinant Adenomatosis Polyposis Coli Protein (APC) - RPC314Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Adenomatosis Polyposis Coli Protein (APC) - RPC314Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Adenomatosis Polyposis Coli Protein (APC) - RPC314Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Protein C, Activated, Human Plasma - 539218 from EMD Millipore Category Protein Source Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. Species Human

HUMAN IgG APC - 009-026-002 from Rockland Immunochemicals Inc Category Protein Prices $98.00 Sizes 500 µl Species Human

HUMAN IgM APC - 009-026-007 from Rockland Immunochemicals Inc Category Protein Prices $139.00 Sizes 250 µl Species Human

APC (pS2054) Blocking Peptide - CBP1056 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey, Pig

APC Blocking Peptide - CBP1057 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Rat, Bovine, Chicken, Pig

APC (Q2829) Peptide - BS1017P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

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