NUPR1

Gene Symbol	NUPR1
Entrez Gene	26471
Alt Symbol	COM1, P8
Species	Human
Gene Type	protein-coding
Description	nuclear protein, transcriptional regulator, 1
Other Description	candidate of metastasis 1\|nuclear protein 1\|protein p8
Swissprots	O60357 B2R5C4 Q6FGG3 O60356
Accessions	AAC05335 AAC05336 AAC19385 EAW52274 EAW52275 EAW52276 O60356 AF069073 AAC19384 AF135266 AAD49221 AK312135 BAG35071 BC002434 AAH02434 BF965595 BP214401 BT006896 AAP35542 CR542144 CAG46941 NM_001042483 NP_001035948 NM_012385 NP_036517
Function	Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin. {ECO:0000269\|PubMed:19650074, ECO:0000269\|PubMed:22565310, ECO:0000269\|PubMed:22858377}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:10092851}.
Tissue Specificity	Widely expressed, with high levels in liver, pancreas, prostate, ovary, colon, thyroid, spinal cord, trachea and adrenal gland, moderate levels in heart, placenta, lung, skeletal muscle, kidney, testis, small intestine, stomach and lymph node, and low levels in brain, spleen, thymus and bone marrow. Not detected in peripheral blood leukocytes. {ECO:0000269\|PubMed:10092851}.
Top Pathways	Transcriptional misregulation in cancer

p8 (T-14) - sc-23283 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

p8 (T-14): sc-23283. Immunofluorescence staining of methanol-fixed MIA PaCa-2 cells showing nuclear localization.

p8 (FL-82) - sc-30184 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-p8 antibody - ab6028 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-p8 antibody - ab93964 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-p8 antibody - ab94034 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-p8 antibody - ab46889 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-p8 antibody [5] - ab87454 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	5

Anti-p8 antibody [5] (ab87454) at 1/1000 dilution + recombinant p8.Observed band size : ~40 kDa (why is the actual band size different from the predicted?)

Anti-NUPR1 Antibody (N-Terminus) - LS-C37960 from LifeSpan Bioscience

Prices	$325.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NUPR1 Antibody (C-Terminus) - LS-C37961 from LifeSpan Bioscience

Prices	$325.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NUPR1 Antibody (N-Terminus) - LS-C40618 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NUPR1 Antibody (C-Terminus) - LS-C40619 from LifeSpan Bioscience

Prices	$275.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-NUPR1 Antibody (aa2-14) - LS-C55224 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-NUPR1 Antibody (C-Terminus) - LS-C151661 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

COM1/p8 Antibody - NBP1-98280 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: COM1/p8 Antibody [NBP1-98280] - 293T Cell Lysate 1.0ug/ml, Gel Concentration: 10-20%

COM1/p8 Antibody - NB300-951 from Novus Biologicals

Prices	$229.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

NUPR1 Polyclonal Antibody - bs-7106R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-NUPR1 (47-60) antibody produced in rabbit - SAB1104559 from Sigma-Aldrich

Prices	$285.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human NUPR1 was separated on SDS-PAGE, blotted with Anti-NUPR1 (47-60) (<B>Cat. No. SAB1104559</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000

NUPR1 antibody - C-terminal region (ARP64233_P050) - ARP64233_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

P8--NUPR1-Antibody-N-Term - AF2397a from Abgent, a WuXi AppTec company

Prices	$325.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

P8 / NUPR1 antibody, N-term - GTX26052 from GeneTex

Prices	$239.00
Sizes	100 μg
Host	Goat
Clonality	Polyclonal

Goat Anti-P8 / NUPR1 Antibody (OAEB00498) - OAEB00498 from Aviva Systems Biology

Prices	$229.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

NUPR1 antibody - 10R-10332 from Fitzgerald

Prices	$375.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	M78702

NUPR1 / COM1 antibody - PAB0975 from Acris Antibodies

Prices	$500.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

NUPR1 / COM1 antibody - PAB0976 from Acris Antibodies

Prices	$500.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-p8 Antibody - AC21-0515 from Abcore

Prices	$359.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

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