SMAD2

Gene Symbol SMAD2
Entrez Gene 4087
Alt Symbol JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2
Species Human
Gene Type protein-coding
Description SMAD family member 2
Other Description MAD homolog 2|SMAD, mothers against DPP homolog 2|Sma- and Mad-related protein 2|mother against DPP homolog 2|mothers against decapentaplegic homolog 2
Swissprots Q15796
Accessions AAC39657 EAW62914 EAW62915 EAW62916 EAW62917 Q15796 AA081871 AA418737 AF027964 AAC51918 AI087928 AI453799 AI765747 AK126373 AK299218 BAH12971 AK312963 BAG35802 AY134745 AAN08619 BC014840 AAH14840 BC025699 AAH25699 BI258844 BQ018815 BQ900993 BT007422 AAP36090 BU167620 BU517178 BX491944 CR992221 DB035686 DB462454 DC371139 DQ891501 ABM82427 DQ893532 ABM84458 DQ893746 ABM84672 DQ894693 ABM85619 U59911 AAC50789 U65019 AAB17054 U68018 AAB17087 XM_005258259 XP_005258316 XM_006722451 XP_006722514 XM_011525983 XP_011524285 XM_011525984 XP_011524286 XM_011525985 XP_011524287 XM_011525986 XP_011524288 NM_001003652 NP_001003652 NM_001135937 NP_001129409 NM_005901 NP_005892
Function Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000269|PubMed:16751101, ECO:0000269|PubMed:16862174, ECO:0000269|PubMed:17327236, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9892009}.
Subcellular Location Cytoplasm. Nucleus. Note=Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
Tissue Specificity Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. {ECO:0000269|PubMed:21599657}.
Top Pathways Chagas disease (American trypanosomiasis), Inflammatory bowel disease (IBD), Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer, Hippo signaling pathway

Smad2 CRISPR/Cas9 KO Plasmid (h) - sc-400475 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad2 HDR Plasmid (h) - sc-400475-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad2 Double Nickase Plasmid (h) - sc-400475-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad2 Double Nickase Plasmid (h2) - sc-400475-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad2 CRISPR Activation Plasmid (h) - sc-400475-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad2 CRISPR Activation Plasmid (h2) - sc-400475-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad2 Lentiviral Activation Particles (h) - sc-400475-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad2 Lentiviral Activation Particles (h2) - sc-400475-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Smad2/3 siRNA (h) - sc-37238 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2/3 shRNA Plasmid (h) - sc-37238-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2/3 shRNA (h) Lentiviral Particles - sc-37238-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2 siRNA (h) - sc-38374 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2 shRNA Plasmid (h) - sc-38374-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2 shRNA (h) Lentiviral Particles - sc-38374-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2 siRNA (h2) - sc-44338 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2 shRNA Plasmid (h2) - sc-44338-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2 shRNA (h2) Lentiviral Particles - sc-44338-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Smad2 RNAi - H00004087-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU069501 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19750 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19750 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SMAD2 siRNA (Human) - CRH2770 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Smad2 RNAi - H00004087-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SMAD2 - MBS8211530 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMAD2 (NM_005901.5) - SHH412960 from Creative biogene

Category siRNA
Species Reactivities Human
Search more