SHMT2

Gene Symbol SHMT2
Entrez Gene 6472
Alt Symbol GLYA, HEL-S-51e, SHMT
Species Human
Gene Type protein-coding
Description serine hydroxymethyltransferase 2 (mitochondrial)
Other Description GLY A+|epididymis secretory sperm binding protein Li 51e|glycine auxotroph A, human complement for hamster|glycine hydroxymethyltransferase|serine aldolase|serine hydroxymethylase|serine hydroxymethyltransferase, mitochondrial|serine methylase|threonine aldolase
Swissprots E7EU43 P34897 O00740 E7EQ19 Q8N1A5 B7Z9F1
Accessions AAA64572 CAA72999 CAY55993 EAW96993 EAW96994 EAW96995 EAW96996 EAW96997 EAW96998 EAW96999 EAW97000 EAW97001 P34897 AK055053 AK223555 BAD97275 AK295941 BAG58725 AK296183 BAG58915 AK297173 BAG59666 AK298231 BAG60500 AK301339 BAG62887 AK301443 BAG62969 AK303827 BAG64774 AK315916 BAH14287 BC008066 BC008711 BC011911 AAH11911 BC013677 AAH13677 BC025355 BC032584 AAH32584 BC044211 AAH44211 BC091501 AAH91501 BT006866 AAP35512 BX647711 CAI46021 BX648847 CN395976 DA052422 DC339924 DC386590 DQ891309 ABM82235 DQ894430 ABM85356 EU668344 ACF94497 L11932 AAA63258 XM_011538675 XP_011536977 XM_011538676 XP_011536978 XM_011538677 XP_011536979 XM_011538678 XP_011536980 NM_001166356 NP_001159828 NM_001166357 NP_001159829 NM_001166358 NP_001159830 NM_001166359 NP_001159831 NM_005412 NP_005403 NR_029415 NR_029416 NR_029417 NR_048562
Function Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. {ECO:0000269|PubMed:21876188}.
Subcellular Location Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane.
Top Pathways Glycine, serine and threonine metabolism, Glyoxylate and dicarboxylate metabolism, Cyanoamino acid metabolism, Biosynthesis of amino acids, Carbon metabolism

SHMT2 Antibody - 12762 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using SHMT2 Antibody.

mSHMT (F-11) - sc-390641 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
mSHMT (F-11): sc-390641. Western blot analysis of mSHMT expression in 293T whole cell lysate.

mSHMT (C-20) - sc-25064 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
mSHMT (C-20): sc-25064. Western blot analysis of mSHMT expression in MCF7 (A), SJRH30 (B) and A-673 (C) whole cell lysates.

mSHMT (H-70) - sc-366621 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
mSHMT (H-70): sc-366621. Western blot analysis of mSHMT expression in MCF7 (A), SJRH30 (B), A-673 (C), Hep G2 (D) and HeLa (E) whole cell lysates.

mSHMT (L-18) - sc-25062 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
mSHMT (L-18): sc-25062. Western blot analysis of mSHMT expression in non-transfected: sc-110760 (A) and human mSHMT transfected: sc-113041 (B) 293 whole cell lysates.

Anti-SHMT2 antibody - ab64417 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SHMT2 antibody (ab64417) at 2.5 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SHMT2 antibody - ab155230 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SHMT2 antibody (ab155230) at 1/10000 dilutionLane 1 : 293T whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 10 µg per lane.

Anti-SHMT2 antibody - ab88664 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-SHMT2 antibody (ab88664) at 1 µg/ml + human spleen tissue lysate at 50 µg

Anti-SHMT2 antibody - C-terminal - ab180786 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat spleen tissue labelling SHMT2 with ab180786 at 1/200. Magnification: 200x.

Anti-SHMT / SHMT2 Antibody - LS-C192477 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SHMT2 pAb in extracts from 293T cells.

Anti-SHMT / SHMT2 Antibody (aa72-121) - LS-C80836 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SHMT2 antibody LS-C80836 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.

Anti-SHMT / SHMT2 Antibody (aa401-450) - LS-C80837 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SHMT2 antibody LS-C80837 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.

Anti-SHMT / SHMT2 Antibody (clone 5E7) - LS-C198191 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5E7
SHMT2 monoclonal antibody (M04), clone 5E7. Western Blot analysis of SHMT2 expression in HeLa.

Anti-SHMT / SHMT2 Antibody - LS-C335135 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat spleen using SHMT2 antibody at dilution of 1:200 (200x lens).

SHMT2 Antibody - NBP1-80755 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SHMT2 Antibody [NBP1-80755] - Analysis in mouse cell line NIH-3T3 and rat cell line NBT-II.

SHMT2 Antibody - NBP1-80754 from Novus Biologicals

Prices $129.00, $419.00
Sizes 25 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SHMT2 Antibody [NBP1-80754] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

SHMT2 Antibody - NBP2-20354 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SHMT2 Antibody - H00006472-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SHMT2 Antibody [H00006472-B01P] - Analysis of SHMT2 expression in human spleen.

SHMT2 Antibody (5E7) - H00006472-M04-100ug from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5E7

Anti-SHMT2 (AB2) antibody produced in rabbit - AV46128 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SHMT2 (ab2): <B>Cat. No. AV46128</B>: Immunohistochemistry of SHMT2 in Human Heart tissue with SHMT2 antibody at 4-8 μg/mL.

Anti-SHMT2 antibody produced in rabbit - HPA020549 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SHMT2: <B>Cat. No. HPA020549</B>: Immunohistochemical staining of human tonsil shows strong positivity in germinal center cells.

Anti-SHMT2 (AB1) antibody produced in rabbit - AV46129 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SHMT2 (ab1): <B>Cat. No. AV46129</B>: Immunohistochemistry of SHMT2 in Human Kidney tissue with SHMT2 antibody at 4-8 μg/mL.

Anti-SHMT2 antibody produced in rabbit - HPA020543 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SHMT2: <B>Cat. No. HPA020543</B>: Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in reaction center cells.

Anti-SHMT2 (431-445) antibody produced in rabbit - SAB1100389 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-SHMT2 (431-445), <B>Cat. No. SAB1100389</B>: Immunofluorescence of HUVEC cells using Anti-SHMT2 (431-445), SAB1100389 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-SHMT2 (36-49) antibody produced in rabbit - SAB1100388 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-SHMT2 (36-49), <B>Cat. No. SAB1100388</B>: Immunofluorescence of HUVEC cells using Anti-SHMT2 (36-49), SAB1100388 (red), taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com
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