Nampt

Gene Symbol Nampt
Entrez Gene 59027
Alt Symbol 1110035O14Rik, AI314458, AI480535, NAmPRTase, Pbef, Pbef1, Visfatin
Species Mouse
Gene Type protein-coding
Description nicotinamide phosphoribosyltransferase
Other Description pre-B-cell colony-enhancing factor 1 homolog
Swissprots Q99KQ4 Q8C3B5 Q9JKM0
Accessions EDL36889 Q99KQ4 AF234625 AAF43208 AK004117 AK086415 BAC39664 AK153926 AK166270 BAE38671 AY679720 AAT72933 BC004059 AAH04059 BC018358 AAH18358 BY068469 CV561474 NM_021524 NP_067499
Function The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD- dependent SIRT1-mediated suppression. {ECO:0000250|UniProtKB:P43490, ECO:0000269|PubMed:12555668, ECO:0000269|PubMed:15381699, ECO:0000269|PubMed:19286518, ECO:0000269|PubMed:19299583}.
Subcellular Location Nucleus {ECO:0000250|UniProtKB:P43490}. Cytoplasm {ECO:0000269|PubMed:12555668}. Secreted {ECO:0000250|UniProtKB:P43490}. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. {ECO:0000250|UniProtKB:P43490}.
Tissue Specificity Ubiquitously expressed in lymphoid and non- lymphoid tissues. {ECO:0000269|PubMed:12555668}.
Top Pathways Nicotinate and nicotinamide metabolism

PBEF CRISPR/Cas9 KO Plasmid (m) - sc-425569 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PBEF HDR Plasmid (m) - sc-425569-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PBEF Double Nickase Plasmid (m) - sc-425569-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PBEF Double Nickase Plasmid (m2) - sc-425569-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PBEF CRISPR Activation Plasmid (m) - sc-425569-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PBEF CRISPR Activation Plasmid (m2) - sc-425569-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PBEF Lentiviral Activation Particles (m) - sc-425569-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PBEF Lentiviral Activation Particles (m2) - sc-425569-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

PBEF siRNA (m) - sc-45844 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

PBEF shRNA Plasmid (m) - sc-45844-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

PBEF shRNA (m) Lentiviral Particles - sc-45844-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU023861 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN36184 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36184 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NAMPT siRNA (Mouse) - CRM6179 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

Mouse Visfatin 1 siRNA - orb285655 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

NAMPT shRNA Plasmid (Mouse) - CHM6179 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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