| Gene Symbol |
KDELR1
|
| Entrez Gene |
10945
|
| Alt Symbol |
ERD2, ERD2.1, HDEL, PM23
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
|
| Other Description |
ER lumen protein retaining receptor 1|ER lumen protein-retaining receptor 1|KDEL endoplasmic reticulum protein retention receptor 1|KDEL receptor 1|putative MAPK-activating protein PM23
|
| Swissprots |
Q54A39 B2R6N4 Q8NBW7 P24390
|
| Accessions |
EAW52340 EAW52341 EAW52342 EAW52343 EAW52344 EAW52345 P24390 AB097047 BAC77400 AK075185 BAC11457 AK312647 BAG35531 BC008958 AAH08958 BC018778 AAH18778 DQ891992 ABM82918 DQ895182 ABM86108 X55885 CAA39371 XM_011526358 XP_011524660 NM_006801 NP_006792
|
| Function |
Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif. COPI-coated transport intermediates, either in the form of round vesicles or as tubular processes, mediate retrograde traffic of the KDEL receptor-ligand complexes. Also required for normal vesicular traffic through the Golgi. {ECO:0000269|PubMed:11703931}.
|
| Subcellular Location |
Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:14517323}; Multi-pass membrane protein {ECO:0000269|PubMed:14517323}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14517323}; Multi-pass membrane protein {ECO:0000269|PubMed:14517323}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:14517323}.
|
| Top Pathways |
Vibrio cholerae infection
|
![Western Blot: KDELR1 Overexpression Lysate (Adult Normal) [NBL1-12220] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KDELR1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2573_KDELR1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12220-img0002.jpg)