Got1

Gene Symbol Got1
Entrez Gene 14718
Alt Symbol AI789014, Got-1, cAspAT, cCAT
Species Mouse
Gene Type protein-coding
Description glutamic-oxaloacetic transaminase 1, soluble
Other Description aspartate aminotransferase, cytoplasmic|cysteine aminotransferase, cytoplasmic|cysteine transaminase, cytoplasmic|cytosolic aspartate aminotransferase|glutamate oxaloacetate transaminase 1, soluble|transaminase A
Swissprots Q3UJH8 P05201
Accessions CAA30275 EDL41904 P05201 AK146445 BAE27177 AK147807 AK147934 AK186873 AK192547 AK195432 AK203412 AK212371 AV574373 BC002057 AAH02057 BY441762 CK334037 J02623 AAA37263 XR_386441 NM_010324 NP_034454
Function Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm.
Tissue Specificity Expressed in neurons of the retina. Localizes to the inner and outer plexiform layers, the inner and outer nuclear layer and the outer segments of photoreceptors. {ECO:0000269|PubMed:21937432}.
Top Pathways Cysteine and methionine metabolism, Alanine, aspartate and glutamate metabolism, Phenylalanine metabolism, Biosynthesis of amino acids, Tyrosine metabolism