| Gene Symbol |
Rab13
|
| Entrez Gene |
81756
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
RAB13, member RAS oncogene family
|
| Other Description |
ras-related protein Rab-13
|
| Swissprots |
P35286 Q8K3X5
|
| Accessions |
EDM00580 EDM00581 P35286 AF525280 AAM82588 FQ222701 M83678 AAA41993 XR_351807 NM_031092 NP_112354
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulatio
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Recycling endosome membrane {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions. Relocalizes to the leading edge of lamellipodia in migrating endothelial cells. {ECO:0000250}.
|
| Tissue Specificity |
Highest levels found in lung, kidney, whole brain and spinal cord. Expressed in all tissues tested including Sertoli and germ cells (at protein level). Also detected in osteoclasts. {ECO:0000269|PubMed:19074001, ECO:0000269|PubMed:22562557}.
|
| Top Pathways |
Tight junction
|