SYK

Gene Symbol	SYK
Entrez Gene	6850
Alt Symbol	p72-Syk
Species	Human
Gene Type	protein-coding
Description	spleen tyrosine kinase
Other Description	tyrosine-protein kinase SYK
Swissprots	P43405
Accessions	EAW62782 EAW62783 EAW62784 EAW62785 EAW62786 P43405 AJ420449 AK057772 AK075020 BAG52053 AK094808 AK290927 BAF83616 AL832053 BC001645 AAH01645 BC002962 AAH02962 BC011399 AAH11399 BG754228 BM019270 BU429809 BX647192 DA587403 DA948098 DB458719 FN391891 CAY55929 FN391892 CAY55930 FN391893 CAY55931 L28824 AAA36526 S80267 AAB35601 W33104 X73568 CAA51970 Z29630 CAA82737 XM_005252147 XP_005252204 XM_011518946 XP_011517248 XM_011518947 XP_011517249 XR_929837 NM_001135052 NP_001128524 NM_001174167 NP_001167638 NM_001174168 NP_001167639 NM_003177 NP_003168
Function	Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR
Subcellular Location	Cell membrane {ECO:0000305}. Cytoplasm, cytosol {ECO:0000305}.
Tissue Specificity	Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is for instance expressed for pro-B-cells to plasma cells. {ECO:0000269|PubMed:8163536}.
Top Pathways	Tuberculosis, Epstein-Barr virus infection, PI3K-Akt signaling pathway, Viral carcinogenesis, Natural killer cell mediated cytotoxicity

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-Syk (Tyr525/526) Sandwich ELISA Kit - 7970 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Phospho-Syk (panTyr) Sandwich ELISA Antibody Pair - 7929 from Cell Signaling Technology Category Antibody Pair

PathScan ® Phospho-Syk (panTyr) Sandwich ELISA Kit - 7928 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

HTScan® Syk Kinase Assay Kit - 7779 from Cell Signaling Technology Category Assay Kit

Phosphotyrosine SYK / Tyrosine-protein Kinase SYK ELISA Kit - RAB0999 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human SYK ELISA Kit (Cell-Based ELISA) - LS-F2338 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-SYK (Tyr525) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1106 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-SYK (Tyr348) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1105 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse/Human/Rat Phospho-SYK (Tyr323) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1225 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 0.313-20 ng/ml

Human SYK ELISA Kit (Sandwich ELISA) - LS-F8590 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 0.313-20 ng/ml

Spleen Tyrosine Kinase (SYK), Human, ELISA Kit - SEE275Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.244ng/mL Range 0.625-40ng/mL

Spleen Tyrosine Kinase, SYK, Human, ELISA Kit - E-EL-H1808 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Tyrosine-protein kinase SYK, SYK, Human, ELISA Kit - E1520h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Spleen Tyrosine Kinase, SYK, Rabbit, ELISA Kit - E-EL-RB1014 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Spleen Tyrosine Kinase, SYK, Chicken, ELISA Kit - E-EL-Ch0074 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Spleen Tyrosine Kinase, SYK, Porcine, ELISA Kit - E-EL-P0336 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Spleen Tyrosine Kinase, SYK, Monkey, ELISA Kit - E-EL-MK1197 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

SYK Colorimetric Cell-Based ELISA Kit - CB5667 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SYK (Phospho-Tyr348) Colorimetric Cell-Based ELISA Kit - CBP1084 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SYK (Phospho-Tyr525) Colorimetric Cell-Based ELISA Kit - CBP1085 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

SYK (Phospho-Tyr323) Colorimetric Cell-Based ELISA Kit - CBP1219 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human SYK(Spleen Tyrosine Kinase) ELISA Kit - E-EL-H1808 from Elabscience Category ELISA Kit Sensitivity 0.38 ng/mL Range 0.63—40 ng/mL

Human SYK (Spleen Tyrosine Kinase) CLIA Kit - E-CL-H1120 from Elabscience Category CLIA Kit Sensitivity 75.00 pg/mL Range Average Recovery (%)

Spleen Tyrosine Kinase, ELISA Kit - MBS050960 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Spleen Tyrosine Kinase, ELISA Kit - MBS089914 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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