FOS

Gene Symbol FOS
Entrez Gene 2353
Alt Symbol AP-1, C-FOS, p55
Species Human
Gene Type protein-coding
Description FBJ murine osteosarcoma viral oncogene homolog
Other Description FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|G0/G1 switch regulatory protein 7|activator protein 1|cellular oncogene c-fos|proto-oncogene c-Fos
Swissprots B4DQ65 P01100 P18849 A8K4E2
Accessions AAA52471 AAC98315 AAO21129 BAA87920 BAA87921 CAA24756 CBX47570 EAW81227 EAW81228 EAW81229 P01100 AK097379 BAG53458 AK290907 BAF83596 AK291326 BAF84015 AK298659 BAG60827 BC004490 AAH04490 BX647104 CR541785 CAG46584 CR542267 CAG47063 DQ893444 ABM84370 DQ896750 ABM87749 S65138 AAB20306 NM_005252 NP_005243
Function Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.
Subcellular Location Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
Top Pathways Toll-like receptor signaling pathway, cAMP signaling pathway, Circadian entrainment, TNF signaling pathway, Prolactin signaling pathway