FOS

Gene Symbol	FOS
Entrez Gene	2353
Alt Symbol	AP-1, C-FOS, p55
Species	Human
Gene Type	protein-coding
Description	FBJ murine osteosarcoma viral oncogene homolog
Other Description	FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS)|G0/G1 switch regulatory protein 7|activator protein 1|cellular oncogene c-fos|proto-oncogene c-Fos
Swissprots	B4DQ65 P01100 P18849 A8K4E2
Accessions	AAA52471 AAC98315 AAO21129 BAA87920 BAA87921 CAA24756 CBX47570 EAW81227 EAW81228 EAW81229 P01100 AK097379 BAG53458 AK290907 BAF83596 AK291326 BAF84015 AK298659 BAG60827 BC004490 AAH04490 BX647104 CR541785 CAG46584 CR542267 CAG47063 DQ893444 ABM84370 DQ896750 ABM87749 S65138 AAB20306 NM_005252 NP_005243
Function	Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. {ECO:0000269|PubMed:16055710, ECO:0000269|PubMed:17160021, ECO:0000269|PubMed:22105363, ECO:0000269|PubMed:7588633, ECO:0000269|PubMed:9732876}.
Subcellular Location	Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. Note=In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
Top Pathways	Toll-like receptor signaling pathway, cAMP signaling pathway, Circadian entrainment, TNF signaling pathway, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-FOS-cDNA-Clone - DC01501 from Abgent, a WuXi AppTec company Prices $513.00 Sizes 10 µg Species Human Accession BC004490

FOS - MBS1270804 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC004490

Human FOS ORF Clone(NM_005252.3) - CDCL163899 from Creative Biomart Species Human Accession NM_005252.3

Human FOS ORF clone - CDCL109087 from Creative Biomart Species Human Accession NM_005252

Human FOS ORF clone - CDCL109088 from Creative Biomart Species Human Accession NM_005252

Human FOS Gene cDNA clone plasmid - HG10075-M from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, C-HA tag - HG10075-CY from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid - HG10075-UT from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, C-His tag - HG10075-CH from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, N-HA tag - HG10075-NY from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10075-M-F from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid - HG10075-M-N from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10075-NF from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10075-CF from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10075-ACG from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10075-NM from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10075-CM from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10075-ANR from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, N-His tag - HG10075-NH from Sino Biological Species Human

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10075-ANG from Sino Biological Species Human

Human FOS ORF Clone (BC004490) - CDCS412161 from Creative biogene Species Human Accession P01100

Human FOS / c-Fos Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10075-ACR from Sino Biological Species Human

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