| Gene Symbol | EPHA2 |
|---|---|
| Entrez Gene | 1969 |
| Alt Symbol | ARCC2, CTPA, CTPP1, CTRCT6, ECK |
| Species | Human |
| Gene Type | protein-coding |
| Description | EPH receptor A2 |
| Other Description | ephrin type-A receptor 2|epithelial cell receptor protein tyrosine kinase|soluble EPHA2 variant 1|tyrosine-protein kinase receptor ECK |
| Swissprots | B5A968 Q8N3Z2 P29317 |
| Accessions | AAL11019 CAI61887 CAM91182 CAT16927 CAV28316 CBX51742 EAW51769 EAW51770 P29317 AI302504 AK296788 BAG59366 BC008655 AAH08655 BC037166 AAH37166 CB991812 DQ895231 ABM86157 EU176326 ABW03777 EU826606 ACF47642 M59371 AAA53375 NM_004431 NP_004422 |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single- pass type I membrane protein. Cell junction, focal adhesion. Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells. |
| Tissue Specificity | Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary. {ECO:0000269|PubMed:17332925}. |
| Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |
Phosphotyrosine EPHA2 / Ephrin Type-A Receptor 2 ELISA Kit - RAB0943 from Sigma-Aldrich
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Human Total EphA2 DuoSet IC Economy Pack, 15 Plate - DYC3035E from R&D Systems
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Human Total EphA2 DuoSet IC ELISA - DYC3035-2 from R&D Systems
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Human Total EphA2 DuoSet IC, 5 Plate - DYC3035-5 from R&D Systems
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Human Phospho-EphA2 DuoSet IC Economy Pk, 15 Plate - DYC4056E from R&D Systems
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Human Phospho-EphA2 DuoSet IC ELISA - DYC4056-2 from R&D Systems
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Human Phospho-EphA2 DuoSet IC, 5 Plate - DYC4056-5 from R&D Systems
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Tyrosine protein kinase receptor A2, EphA2, Human, ELISA Kit - E-EL-H0861 from ARP American Research Products
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Tyrosine protein kinase receptor A2, EphA2, Rabbit, ELISA Kit - E-EL-RB0976 from ARP American Research Products
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Tyrosine protein kinase receptor A2, EphA2, Chicken, ELISA Kit - E-EL-Ch0903 from ARP American Research Products
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Tyrosine protein kinase receptor A2, EphA2, Porcine, ELISA Kit - E-EL-P0848 from ARP American Research Products
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Tyrosine protein kinase receptor A2, EphA2, Guinea Pig, ELISA Kit - E-EL-GP0453 from ARP American Research Products
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Tyrosine protein kinase receptor A2, EphA2, Monkey, ELISA Kit - E-EL-MK1243 from ARP American Research Products
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EPHA2 (Human) Matched Antibody Pair - H00001969-AP11 from Acris Antibodies
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EPHA2 (Human) Matched Antibody Pair - H00001969-AP21 from Acris Antibodies
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EPHA2 (Human) Matched Antibody Pair - H00001969-AP51 from Acris Antibodies
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Custom Human EphA2 ELISA - ELH-EPHA2 from RayBiotech
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EPH receptor A2, ELISA Kit - MBS934536 from MyBioSource
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EPHA2/3/4 Colorimetric Cell-Based ELISA Kit - CB5233 from Assay Biotechnology
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EPHA2/3/4 (Phospho-Tyr588/596) Colorimetric Cell-Based ELISA Kit - CBP1365 from Assay Biotechnology
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Human EphA2(Tyrosine protein kinase receptor A2) ELISA Kit - E-EL-H0861 from Elabscience
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Human EphA2 (Tyrosine protein kinase receptor A2) CLIA Kit - E-CL-H0597 from Elabscience
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EphA2, ELISA Kit - MBS2500407 from MyBioSource
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EphA2, ELISA Kit - MBS2513469 from MyBioSource
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EphA2, ELISA Kit - MBS2510511 from MyBioSource
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