| Gene Symbol |
NAT8B
|
| Entrez Gene |
51471
|
| Alt Symbol |
CML2, Hcml2, NAT8BP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)
|
| Other Description |
ATase1|N-acetyltransferase Camello 2|acetyltransferase 1|camello-like protein 2|probable N-acetyltransferase 8B|putative N-acetyltransferase 8B
|
| Swissprots |
Q0VAD9 Q9UHF3 Q6NT18
|
| Accessions |
EAW99724 Q9UHF3 AF185571 AAF22299 BC069564 BC121101 BC121102 BC160071 AAI60071 BX105650 NM_016347 NP_057431
|
| Function |
May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons (PubMed:19011241). {ECO:0000269|PubMed:19011241, ECO:0000269|PubMed:24556617}.
|
| Subcellular Location |
Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Enriched in the Endoplasmic reticulum-Golgi intermediate compartment.
|
![Western Blot: CML2 Overexpression Lysate (Adult Normal) [NBL1-13492] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CML2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4663_CML2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13492-img0002.jpg)