| Gene Symbol |
CXCR4
|
| Entrez Gene |
7852
|
| Alt Symbol |
CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-X-C motif) receptor 4
|
| Other Description |
C-X-C chemokine receptor type 4|CD184 antigen|LPS-associated protein 3|SDF-1 receptor|fusin|leukocyte-derived seven transmembrane domain receptor|lipopolysaccharide-associated protein 3|neuropeptide Y receptor Y3|seven transmembrane helix receptor|seven-transmembrane-segment receptor, spleen|stromal cell-derived factor 1 receptor
|
| Swissprots |
Q9BXA0 Q9UKN2 O60835 P61073 P56438 Q53S69 P30991 B2R5N0
|
| Accessions |
AAB93982 AAC34581 AAU05775 AAY24044 BAC05813 CAA12166 CAA75034 CBG22675 CBJ06540 EAX11616 P61073 AF025375 AAB81970 AF147204 AAF00130 AF348491 AAK29630 AK129916 AK296674 BAG59271 AK309641 AK309885 AK312244 BAG35177 AY242129 AAO92296 AY826773 AAV97584 BC020968 AAH20968 BT006660 AAP35306 D10924 BAA01722 D28433 BAA05799 EU831811 ACE87329 EU831888 ACE86647 JF432649 ADZ15866 L01639 AAA16594 L06797 AAA03209 M99293 AAA16617 X71635 CAA50641 NM_001008540 NP_001008540 NM_003467 NP_003458
|
| Function |
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. {ECO:0000269|PubMed:10074102, ECO:0000269|PubMed:10644702, ECO:0000269|PubMed:10825158
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
|
| Tissue Specificity |
Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. {ECO:0000269|PubMed:11276205}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Axon guidance, Leukocyte transendothelial migration, Endocytosis, Intestinal immune network for IgA production
|