GNL3L

Gene Symbol GNL3L
Entrez Gene 54552
Alt Symbol -
Species Human
Gene Type protein-coding
Description guanine nucleotide binding protein-like 3 (nucleolar)-like
Other Description guanine nucleotide-binding protein-like 3-like protein|novel GTPase
Swissprots Q9NVN8
Accessions CAE89448 CBX47629 EAW93182 EAW93183 EAW93184 EAW93185 Q9NVN8 AK001475 BAA91712 AK022325 AK128277 BC003603 AAH03603 BC011720 AAH11720 BC022829 BQ674906 XM_011530799 XP_011529101 NM_001184819 NP_001171748 NM_019067 NP_061940
Function Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:17034816}.
Top Pathways Ribosome biogenesis in eukaryotes

GNL3L CRISPR/Cas9 KO Plasmid (h) - sc-412308 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GNL3L HDR Plasmid (h) - sc-412308-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GNL3L Double Nickase Plasmid (h) - sc-412308-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GNL3L Double Nickase Plasmid (h2) - sc-412308-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GNL3L CRISPR Activation Plasmid (h) - sc-412308-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GNL3L CRISPR Activation Plasmid (h2) - sc-412308-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GNL3L Lentiviral Activation Particles (h) - sc-412308-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GNL3L Lentiviral Activation Particles (h2) - sc-412308-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GNL3L siRNA (h) - sc-91125 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GNL3L shRNA Plasmid (h) - sc-91125-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GNL3L shRNA (h) Lentiviral Particles - sc-91125-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN9438 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9438 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GNL3L siRNA (Human) - CRJ0132 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GNL3L - MBS8203398 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GNL3L (NM_019067.5) - SHH305006 from Creative biogene

Category siRNA
Species Reactivities Human

GNL3L shRNA Plasmid (Human) - CHJ0132 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GNL3L miRNA 3'UTR clone - MiUTR4H-TG03892 from Creative biogene

Species Reactivities Human
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