Got2

Gene Symbol Got2
Entrez Gene 25721
Alt Symbol ASPATA
Species Rat
Gene Type protein-coding
Description glutamic-oxaloacetic transaminase 2, mitochondrial
Other Description FABP-1|FABPpm|Glutamate oxaloacetate transaminase 2, mitochondrial (aspartate aminotransferase 2)|aspartate aminotransferase, mitochondrial|fatty acid-binding protein|glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)|kynurenine aminotransferase 4|kynurenine aminotransferase IV|kynurenine--oxoglutarate transaminase 4|kynurenine--oxoglutarate transaminase IV|mAspAT|plasma membrane-associated fatty acid-binding protein|transaminase A
Swissprots Q64551 Q9QV50 P00507
Accessions CBF96250 CBV09770 EDL87266 P00507 BC061792 AAH61792 CB607680 FM056810 FQ210345 M12709 AAA41267 M18467 AAB54275 NM_013177 NP_037309
Function Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). {ECO:0000250}.
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:11962739}. Cell membrane {ECO:0000269|PubMed:11962739}. Note=Located in the mitochondria of liver, pancreas, spleen, heart, pituitary gland and submandibular gland cells. In kidney, located in the mitochondria, on the cell surface of regions with protrusions in distal tubules, on the apical cell surface of protrusions along the microvilli in cortical collecting ducts, in condensing vacuoles, on the cell surface at cell boundaries of adjoining kidney cells and on the cell surface of endothelial cells lining capillaries in the glomerulus. Also located at the cell surface of endothelial cells lining arterioles and on the cell surface of lymphocytes.
Tissue Specificity Expressed in all tissues tested: liver, pancreas, kidney, heart, spleen, arterioles, and lymphocytes. {ECO:0000269|PubMed:11962739}.
Top Pathways Cysteine and methionine metabolism, Fat digestion and absorption, Alanine, aspartate and glutamate metabolism, 2-Oxocarboxylic acid metabolism, Carbon metabolism

CompoZr® Knockout ZFN Kit - CKOZFN54590 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND54590 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

GOT2 siRNA (Rat) - CRR0904 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

GOT2 - MBS8228943 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Rat

shRNA set against Rat GOT2 (NM_013177.2) - SHH305514 from Creative biogene

Category siRNA
Species Reactivities Rat

GOT2 shRNA Plasmid (Rat) - CHR0904 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Rat
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