XRCC4

Gene Symbol XRCC4
Entrez Gene 7518
Alt Symbol -
Species Human
Gene Type protein-coding
Description X-ray repair complementing defective repair in Chinese hamster cells 4
Other Description DNA repair protein XRCC4|X-ray repair cross-complementing protein 4|X-ray repair, complementing defective, repair in Chinese hamster
Swissprots Q13426 Q9UP94 A8K3X4 Q9BS72
Accessions AAD47297 AAD47298 AAX14046 EAW95897 EAW95898 EAW95899 EAW95900 EAW95901 EAW95902 Q13426 AB017445 BAB20668 AK290739 BAF83428 BC005259 AAH05259 BC010655 AAH10655 BC016314 AAH16314 BT007216 AAP35880 DA067761 EU832713 ACE87045 U40622 AAC50339 XM_005248595 XP_005248652 XM_011543626 XP_011541928 XM_011543627 XP_011541929 XM_011543628 XP_011541930 XM_011543629 XP_011541931 NM_003401 NP_003392 NM_022406 NP_071801 NM_022550 NP_072044
Function Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. {ECO:0000269|PubMed:10757784, ECO:0000269|PubMed:10854421, ECO:0000269|PubMed:16412978, ECO:0000269|PubMed:8548796}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16478998, ECO:0000269|PubMed:9259561}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:8548796}.
Top Pathways Non-homologous end-joining

XRCC4 (A-7) - sc-365055 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRCC4 (A-7): sc-365055. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

XRCC4 (C-20) - sc-8285 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRCC4 (C-20): sc-8285. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

XRCC4 (C-4) - sc-271087 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRCC4 (C-4): sc-271087. Western blot analysis of XRCC4 expression in HCT 116 (A) and T-47D (B) whole cell lysates and K-562 (C) and HeLa (D) nuclear extracts.

XRCC4 (H-18) - sc-5388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
XRCC4 (H-18): sc-5388. Immunoperoxidase staining of formalin fixed, paraffin-embedded human vulva/anal skin tissue showing nuclear and cytoplasmic staining of epidermal cells.

XRCC4 (G-10) - sc-365118 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
XRCC4 (G-10): sc-365118. Western blot analysis of XRCC4 expression in MOLT-4 (A), HCT 116 (B) and KNRK (C) whole cell lysates.

XRCC4 (H-233) - sc-5606 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

XRCC4 (4) - sc-136124 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
XRCC4 (4): sc-136124. Western blot analysis of XRCC4 expression in HeLa whole cell lysate.

Anti-XRCC4 antibody - ab97351 from Abcam

Prices $394.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XRCC4 antibody (ab97351) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : HeLaS3 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-XRCC4 antibody - ab58468 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XRCC4 antibody (ab58468) at 1/500 dilutionLane 1 : extracts from COLO205 cells with no immunising peptideLane 2 : extracts from COLO205 cells with immunising peptide

Anti-XRCC4 antibody - ab139092 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-XRCC4 antibody (ab139092) at 1/100 dilution + A549 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-XRCC4 antibody [4H9] - ab118008 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H9
All lanes : Anti-XRCC4 antibody [4H9] (ab118008) at 1/2000 dilutionLane 1 : HEK293T lysate transfected with pCMV6-ENTRY control cDNA for 48 hrsLane 2 : HEK293T lysate transfected with pCMV6-ENTRY XRCC4 cDNA for 48 hrsLysates/proteins at 5 µg per lane.

Anti-XRCC4 antibody - ChIP Grade - ab145 from Abcam

Prices $394.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-XRCC4 antibody - ChIP Grade (ab145) at 1/2000 dilution + HeLa nuclear extract SecondarySHEEP ANTI RABBIT IgG:HRP

Anti-XRCC4 antibody - N-terminal - ab157147 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-XRCC4 antibody - N-terminal (ab157147) at 1/3000 dilutionLane 1 : Human SKOV cell lysateLane 3 : K1 CHO cell lysateLane 5 : XR1 CHO cell lysateLane 6 : xrs6 CHO cell lysateLysates/proteins at 20 µg per lane.SecondaryLane 1 : Alkaline Phosphatase conjugated goat-anti rabbit IgG polyclonal at 1/3000 dilutionLanes 3, 5 & 6 : Alkaline Phosphatase conjugated goat anti-rabbit IgG polyclonal at 1/3000 dilutionPerformed under reducing conditions.

Anti-XRCC4 Antibody (clone 4H9) - LS-C114745 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H9
IHC of paraffin-embedded Carcinoma of thyroid tissue using anti-XRCC4 mouse monoclonal antibody. (Dilution 1:50).

Anti-XRCC4 Antibody - LS-C331631 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using XRCC4 antibody.

Anti-XRCC4 Antibody (aa216-309) - LS-C186088 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
XRCC4 antibody detects XRCC4 protein at nucleus on HBL435 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded HBL435 xenograft. XRCC4 antibody dilution:1:500.

Anti-XRCC4 Antibody - LS-C11117 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-XRCC4 Antibody - LS-C11118 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC4 Antibody - LS-C20088 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-XRCC4 Antibody - LS-C192937 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-XRCC4 Antibody (aa205-234, AP) - LS-C218456 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC4 Antibody - LS-C42684 from LifeSpan Bioscience

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western blot of HeLa nuclear extract probed with Rabbit anti- XRCC4 (LS-C42684) followed by Sheep anti-Rabbit IgG:HRP (STAR54).

Anti-XRCC4 Antibody (aa205-234, Biotin) - LS-C218458 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC4 Antibody (aa205-234, APC) - LS-C218457 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-XRCC4 Antibody (aa205-234, FITC) - LS-C218459 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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