| Gene Symbol | Mmp14 |
|---|---|
| Entrez Gene | 17387 |
| Alt Symbol | AI325305, MT-MMP-1, MT1-MMP, sabe |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | matrix metallopeptidase 14 (membrane-inserted) |
| Other Description | MMP-14|MMP-X1|MT-MMP 1|MT1MMP|MTMMP1|Membrane type 1-MMP|matrix metalloproteinase 14 (membrane-inserted)|matrix metalloproteinase-14|membrane-type matrix metalloproteinase 1|membrane-type-1 matrix metalloproteinase|type 1 matrix metalloprotease 14 |
| Swissprots | Q8BTX2 P53690 O08645 O35369 |
| Accessions | AAB86602 EDL36348 EDL36349 P53690 AK040968 AK088476 BAC40377 AK134340 AK138611 BAE23719 AK149636 AK149907 BAE29158 AK149988 BAE29216 AK155117 BAE33060 AK163601 BAE37413 AK165014 BAE38000 AK180055 AK180818 AK182079 AK182471 AK183589 AK185366 AK185474 AK186174 AK186619 AK186724 AK189221 AK189497 AK194864 AK198018 AK198345 AK203136 AK206887 AK208886 AK209696 AK212086 AK212295 AK212401 AK212820 AK217153 AK218911 AK218925 AK219528 AY622974 AAT46405 BC076638 AAH76638 BY700899 DQ249870 ABB45784 U54984 AAB51753 X83536 CAA58520 NM_008608 NP_032634 |
| Function | Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Melanosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Forms a complex with BST2 and localizes to the cytoplasm. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in placenta, kidney, heart, lung, embryonic skeletal and periskeletal tissues. |
| Top Pathways | GnRH signaling pathway, TNF signaling pathway |
MT-MMP-1 CRISPR/Cas9 KO Plasmid (m) - sc-421671 from Santa Cruz Biotechnology
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MT-MMP-1 HDR Plasmid (m) - sc-421671-HDR from Santa Cruz Biotechnology
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MT-MMP-1 Double Nickase Plasmid (m) - sc-421671-NIC from Santa Cruz Biotechnology
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MT-MMP-1 Double Nickase Plasmid (m2) - sc-421671-NIC-2 from Santa Cruz Biotechnology
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MT-MMP-1 CRISPR Activation Plasmid (m) - sc-421671-ACT from Santa Cruz Biotechnology
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MT-MMP-1 CRISPR Activation Plasmid (m2) - sc-421671-ACT-2 from Santa Cruz Biotechnology
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MT-MMP-1 Lentiviral Activation Particles (m) - sc-421671-LAC from Santa Cruz Biotechnology
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MT-MMP-1 Lentiviral Activation Particles (m2) - sc-421671-LAC-2 from Santa Cruz Biotechnology
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MT-MMP-1 siRNA (m) - sc-41566 from Santa Cruz Biotechnology
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MT-MMP-1 shRNA Plasmid (m) - sc-41566-SH from Santa Cruz Biotechnology
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MT-MMP-1 shRNA (m) Lentiviral Particles - sc-41566-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU050191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN35644 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND35644 from Sigma-Aldrich
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MMP14 siRNA (Mouse) - CRM2558 from Cohesion Biosciences
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shRNA set against Mouse MMP14 (NM_008608.3) - SHH342916 from Creative biogene
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MMP14 shRNA Plasmid (Mouse) - CHM2558 from Cohesion Biosciences
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