| Gene Symbol |
Cpeb1
|
| Entrez Gene |
12877
|
| Alt Symbol |
AU024112, Cpeb, mCPEB
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cytoplasmic polyadenylation element binding protein 1
|
| Other Description |
CPE-BP1|CPE-binding protein 1|cytoplasmic polyadenylation element-binding protein 1|mCPEB-1
|
| Swissprots |
Q8C5P9 P70166
|
| Accessions |
EDL06946 P70166 AK077799 BAC37017 AK135615 AK136088 AK199617 AK207851 BC125476 AAI25477 BC144948 BY720025 CO803180 Y08260 CAA69588 XM_011250784 XP_011249086 XM_011250785 XP_011249087 XM_011250786 XP_011249088 XM_011250787 XP_011249089 XM_011250788 XP_011249090 XM_011250789 XP_011249091 XM_011250790 XP_011249092 XM_011250791 XP_011249093 XM_011250792 XP_011249094 NM_001252525 NP_001239454 NM_001252526 NP_001239455 NM_007755 NP_031781
|
| Function |
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU- 3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Membrane {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Localizes in synaptosomes at dendritic synapses of neurons. Strongly enriched in postsynaptic density (PSD) fractions. Transported into dendrites in a microtubule- dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin. Membrane-associated. Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA, SYP, etc.) including CPE-containing RNAs. In P-bodies and stress granules (By similarity). Recruited to stress granules (SGs) upon arsenite treatment (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in hippocampus, cerebral cortex and oocytes (at protein level). Expressed in brain, heart, kidney, lung and ovary and testis. Weakly expressed in granular cells of dentate gyrus and the pyramidal cells of CA3 and CA1 of the hippocampus. {ECO:0000269|PubMed:11526086, ECO:0000269|PubMed:11980711, ECO:0000269|PubMed:12871996, ECO:0000269|PubMed:8962099, ECO:0000269|PubMed:9856468}.
|
| Top Pathways |
Progesterone-mediated oocyte maturation, Oocyte meiosis, Dorso-ventral axis formation
|