| Gene Symbol | BIRC2 |
|---|---|
| Entrez Gene | 329 |
| Alt Symbol | API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | baculoviral IAP repeat containing 2 |
| Other Description | IAP homolog B|IAP-2|NFR2-TRAF signalling complex protein|RING finger protein 48|TNFR2-TRAF-signaling complex protein 2|apoptosis inhibitor 1|baculoviral IAP repeat-containing 2|baculoviral IAP repeat-containing protein 2|inhibitor of apoptosis protein 2 |
| Swissprots | B4E026 Q16516 Q13490 Q4TTG0 |
| Accessions | AAY46158 EAW67018 Q13490 AK225856 AK303197 BAG64288 AK313446 BAG36235 BC016174 AAH16174 BC028578 AAH28578 BX647978 DA094075 DA115985 DQ892384 ABM83310 DQ895596 ABM86522 L49431 AAC41942 U37547 AAC50508 U45879 AAC50372 NM_001166 NP_001157 NM_001256163 NP_001243092 NM_001256166 NP_001243095 |
| Function | Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptor |
| Subcellular Location | Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells. |
| Tissue Specificity | Present in many fetal and adult tissues. Mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. |
| Top Pathways | NOD-like receptor signaling pathway, TNF signaling pathway, Hippo signaling pathway, Toxoplasmosis, Apoptosis |