Ripk3

Gene Symbol Ripk3
Entrez Gene 56532
Alt Symbol 2610528K09Rik, AW107945, Rip3
Species Mouse
Gene Type protein-coding
Description receptor-interacting serine-threonine kinase 3
Other Description RIP-3|RIP-like protein kinase 3|mRIP3|receptor interacting protein 3|receptor-interacting protein 3|receptor-interacting serine/threonine-protein kinase 3
Swissprots Q8K2Y2 Q3U3Z9 G3X8V8 Q9QZL0
Accessions EDL36235 EDL36236 Q9QZL0 AA270784 AF178953 AAF03133 AK012177 AK154505 BAE32636 BC029210 AAH29210 BF658559 BY206463 BY209344 NM_001164107 NP_001157579 NM_001164108 NP_001157580 NM_019955 NP_064339
Function Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. {ECO:0000269|PubMed:19590578, ECO:0000269|PubMed:24012422, ECO:0000269|PubMed:24019532, ECO:0000269|PubMed:24095729}.
Subcellular Location Cytoplasm, cytosol {ECO:0000305}. Cell membrane. Mitochondrion {ECO:0000305}.
Tissue Specificity Expressed in embryo and in adult spleen, liver, testis, heart, brain and lung.
Top Pathways Cytosolic DNA-sensing pathway, TNF signaling pathway

SignalSilence ® RIP3 siRNA I (Mouse Specific) - 14645 from Cell Signaling Technology

Category siRNA
Prices $249.00
Sizes 300 µl (3 nmol)
Western blot analysis of extracts from L-929 cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® RIP3 siRNA I (Mouse Specific) (+), or SignalSilence ® RIP3 siRNA II (Mouse Specific) #14661 (+), using RIP3 Antibody (Rodent Specific) #14401 (upper) and α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower). The RIP3 Antibody (Rodent Specific) confirms silencing of RIP3 expression, while the α-Actinin (D6F6) XP ® Rabbit mAb is used as a loading control.

SignalSilence ® RIP3 siRNA II (Mouse Specific) - 14661 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (3 nmol)
Species Reactivities Mouse
Western blot analysis of extracts from L-929 cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-), SignalSilence ® RIP3 siRNA I (Mouse Specific) #14645 (+), or SignalSilence ® RIP3 siRNA II (Mouse Specific) (+), using RIP3 Antibody (Rodent Specific) #14401 (upper) and α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower). The RIP3 Antibody (Rodent Specific) confirms silencing of RIP3 expression, while the α-Actinin (D6F6) XP ® Rabbit mAb is used as a loading control.

RIP3 CRISPR/Cas9 KO Plasmid (m) - sc-425224 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

RIP3 HDR Plasmid (m) - sc-425224-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

RIP3 Double Nickase Plasmid (m) - sc-425224-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

RIP3 Double Nickase Plasmid (m2) - sc-425224-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

RIP3 CRISPR Activation Plasmid (m) - sc-425224-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

RIP3 CRISPR Activation Plasmid (m2) - sc-425224-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

RIP3 Lentiviral Activation Particles (m) - sc-425224-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

RIP3 Lentiviral Activation Particles (m2) - sc-425224-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

RIP3 siRNA (m) - sc-61483 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

RIP3 shRNA Plasmid (m) - sc-61483-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

RIP3 shRNA (m) Lentiviral Particles - sc-61483-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU025421 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN40262 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40262 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RIPK3 siRNA (Mouse) - CRM5855 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

RIPK3 - MBS8205891 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse RIPK3 (NM_019955.2) - SHH396024 from Creative biogene

Category siRNA
Species Reactivities Mouse

RIPK3 shRNA Plasmid (Mouse) - CHM5855 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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