ACVR2B

Gene Symbol ACVR2B
Entrez Gene 93
Alt Symbol ACTRIIB, ActR-IIB, HTX4
Species Human
Gene Type protein-coding
Description activin A receptor, type IIB
Other Description activin receptor type-2B
Swissprots Q4VAV0 Q13705
Accessions AAC64515 BAA24180 EAW64536 Q13705 AB209449 BAD92686 AF075005 AAC28458 BC096243 AAH96243 BC096244 AAH96244 BC096245 AAH96245 BC099642 AAH99642 BP352716 X77533 CAA54671 XM_005265583 XP_005265640 NM_001106 NP_001097
Function Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated rece
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Top Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

ACTR-IIB (D-25) - sc-130938 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

ACTR-IIB (G-7) - sc-376593 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ACTR-IIB (G-7): sc-376593. Western blot analysis of ACTR-IIB expression in Jurkat whole cell lysate.

ACTR-IIB (H-70) - sc-25453 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ACTR-IIB (H-70): sc-25453. Western blot analysis of ACTR-IIB expression in NIH/3T3 whole cell lysate.

ACTR-IIB (N-16) - sc-5665 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ACTR-IIB (N-16): sc-5665. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of decidual cells.

ACTR-IIB (ACEX12) - sc-73682 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ACTR-IIB (ACEX12): sc-73682. Western blot analysis of ACTR-IIB expression in Hep G2 (A), HeLa (B), Jurkat (C), K-562 (D) and Ramos (E) whole cell lysates.

ACTR-IIB (9D10) - sc-134245 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ACTR-IIB (9D10): sc-134245. Western blot analysis of ACTR-IIB expression in Jurkat (A) and K-562 (B) whole cell lysates.

Anti-Activin Receptor Type IIB antibody - ab128544 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Activin Receptor Type IIB antibody (ab128544) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : PANC-1 cell lysate

Anti-Activin Receptor Type IIB antibody - ab10596 from Abcam

Prices $378.00
Sizes 25 µg
Host Goat
Clonality Polyclonal
ACVR2B staining was mainly localized at the membrane level of the epithelial cells in the normal tissues with a clear down-regulation in tumoral epithelia.

Anti-Activin Receptor Type IIB antibody - ab116315 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Activin Receptor Type IIB antibody (ab116315) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

Anti-Activin Receptor Type IIB antibody [EPR10739] - ab180185 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10739
All lanes : Anti-Activin Receptor Type IIB antibody [EPR10739] (ab180185) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : NIH:OVCAR-3 cell lysateLane 3 : 293T cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-Activin Receptor Type IIB antibody - N-terminal - ab135635 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Activin Receptor Type IIB antibody - N-terminal (ab135635) at 1/100 dilution + Jurkat cell line lysate at 35 µg

Anti-ACTRIIB / ACVR2B Antibody (Extracellular Domain) - LS-C345072 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot with extracellular domains (ecd) of different related human receptors (50ng per lane) reveals that anti-Activin Receptor IIB, pAb (IG-510) (dilution 1:5000) specifically recoginzes ACTR-IIB under non reducing (-[Character df]ME, left panel) and reducing (+[Character df]ME; right panel) conditions, but none of the other receptor types tested.

Anti-ACTRIIB / ACVR2B Antibody (aa287-336) IHC-plus™ - LS-B11133 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ACTRIIB / ACVR2B antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11133 concentration 10 ug/ml.

Anti-ACTRIIB / ACVR2B Antibody (aa1-30) IHC-plus™ - LS-B7781 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-ACTRIIB / ACVR2B antibody IHC of human placenta, trophoblast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7781 dilution 10 ug/ml.

Anti-ACTRIIB / ACVR2B Antibody (aa323-372) IHC-plus™ - LS-B11932 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-ACTRIIB / ACVR2B Antibody (C-Terminus) - LS-C98087 from LifeSpan Bioscience

Prices $250.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ACTRIIB / ACVR2B Antibody (Extracellular Domain, Biotin) - LS-C124889 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-ACTRIIB / ACVR2B Antibody (Extracellular Domain, clone 60408) - LS-C124890 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal
Clone 60408

Anti-ACTRIIB / ACVR2B Antibody (Extracellular Domain, clone 60402) - LS-C124891 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 60402

Anti-ACTRIIB / ACVR2B Antibody (aa148-176, AP) - LS-C250809 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACTRIIB / ACVR2B Antibody (aa148-176, FITC) - LS-C252817 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACTRIIB / ACVR2B Antibody (aa148-176, Azide-free, HRP) - LS-C252818 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACTRIIB / ACVR2B Antibody (aa148-176, APC) - LS-C250810 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACTRIIB / ACVR2B Antibody (aa148-176, Biotin) - LS-C250811 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACTRIIB / ACVR2B Antibody (aa148-176, PE) - LS-C252819 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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