Gene Symbol | ARIH1 |
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Entrez Gene | 25820 |
Alt Symbol | ARI, HARI, HHARI, UBCH7BP |
Species | Human |
Gene Type | protein-coding |
Description | ariadne RBR E3 ubiquitin protein ligase 1 |
Other Description | ARI-1|E3 ubiquitin-protein ligase ARIH1|H7-AP2|MOP-6|ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1|ariadne, Drosophila, homolog of|monocyte protein 6|protein ariadne-1 homolog|ubcH7-binding protein|ubcM4-interacting protein|ubiquitin-conjugating enzyme E2-binding protein 1 |
Swissprots | Q9UP39 Q9H3T6 O76026 B2R6U3 Q9UEN0 Q9Y4X5 |
Accessions | CAH05382 EAW77907 EAW77908 Q9Y4X5 AB014774 BAB19786 AB209432 BAD92669 AF072832 AAD28088 AJ009771 CAA08817 AJ130976 CAA10274 AJ243190 CAB45870 AK000336 AK312715 BAG35590 AL117650 BC051877 AAH51877 BX641117 XM_011521438 XP_011519740 XM_011521439 XP_011519741 NM_005744 NP_005735 |
Function | E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2. {ECO:0000269|PubMed:14623119, ECO:0000269|PubMed:15236971, ECO:0000269|PubMed:17289916, ECO:0000269|PubMed:21532592}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11278816}. Note=Mainly cytoplasmic. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10521492}. |
ARIH1 CRISPR/Cas9 KO Plasmid (h) - sc-407954 from Santa Cruz Biotechnology
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ARIH1 HDR Plasmid (h) - sc-407954-HDR from Santa Cruz Biotechnology
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ARIH1 Double Nickase Plasmid (h) - sc-407954-NIC from Santa Cruz Biotechnology
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ARIH1 Double Nickase Plasmid (h2) - sc-407954-NIC-2 from Santa Cruz Biotechnology
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ARIH1 CRISPR Activation Plasmid (h) - sc-407954-ACT from Santa Cruz Biotechnology
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ARIH1 CRISPR Activation Plasmid (h2) - sc-407954-ACT-2 from Santa Cruz Biotechnology
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ARIH1 Lentiviral Activation Particles (h) - sc-407954-LAC from Santa Cruz Biotechnology
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ARIH1 Lentiviral Activation Particles (h2) - sc-407954-LAC-2 from Santa Cruz Biotechnology
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ARIH1 siRNA (h) - sc-90171 from Santa Cruz Biotechnology
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ARIH1 shRNA Plasmid (h) - sc-90171-SH from Santa Cruz Biotechnology
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ARIH1 shRNA (h) Lentiviral Particles - sc-90171-V from Santa Cruz Biotechnology
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ARIH1 RNAi - H00025820-R01 from Novus Biologicals
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MISSION® esiRNA - EHU004871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3475 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3475 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01120 from Sigma-Aldrich
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ARIH1 siRNA (Human) - CRH8519 from Cohesion Biosciences
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ARIH1 - MBS8204542 from MyBioSource
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shRNA set against Human ARIH1 (NM_005744.3) - SHH240046 from Creative biogene
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Human ARIH1 siRNA - orb269021 from Biorbyt
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ARIH1 shRNA Plasmid (Human) - CHH8519 from Cohesion Biosciences
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ARIH1 miRNA 3'UTR clone - MiUTR4H-TG00492 from Creative biogene
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