CSNK2A2
| Gene Symbol | CSNK2A2 |
|---|---|
| Entrez Gene | 1459 |
| Alt Symbol | CK2A2, CSNK2A1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | casein kinase 2, alpha prime polypeptide |
| Other Description | CK II alpha'|casein kinase II subunit alpha' |
| Swissprots | P19784 |
| Accessions | EAW82969 P19784 AI150700 AK090752 AK125922 BC008812 AAH08812 DQ893025 ABM83951 DQ896269 ABM87268 M55268 AAA51548 XM_005255800 XP_005255857 XM_005255801 XP_005255858 NM_001896 NP_001887 |
| Function | Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activat |
| Top Pathways | Wnt signaling pathway, Adherens junction, Tight junction, Ribosome biogenesis in eukaryotes, Measles |
casein kinase IIα′ CRISPR/Cas9 KO Plasmid (h) - sc-401148 from Santa Cruz Biotechnology
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casein kinase IIα’ HDR Plasmid (h) - sc-401148-HDR from Santa Cruz Biotechnology
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casein kinase IIα′ Double Nickase Plasmid (h) - sc-401148-NIC from Santa Cruz Biotechnology
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casein kinase IIα′ Double Nickase Plasmid (h2) - sc-401148-NIC-2 from Santa Cruz Biotechnology
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casein kinase IIα′ CRISPR Activation Plasmid (h) - sc-401148-ACT from Santa Cruz Biotechnology
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casein kinase IIα′ CRISPR Activation Plasmid (h2) - sc-401148-ACT-2 from Santa Cruz Biotechnology
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casein kinase IIα′ Lentiviral Activation Particles (h) - sc-401148-LAC from Santa Cruz Biotechnology
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casein kinase IIα′ Lentiviral Activation Particles (h2) - sc-401148-LAC-2 from Santa Cruz Biotechnology
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casein kinase IIα′ siRNA (h) - sc-38963 from Santa Cruz Biotechnology
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casein kinase IIα′ shRNA Plasmid (h) - sc-38963-SH from Santa Cruz Biotechnology
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casein kinase IIα′ shRNA (h) Lentiviral Particles - sc-38963-V from Santa Cruz Biotechnology
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CKII alpha prime polypeptide RNAi - H00001459-R02 from Novus Biologicals
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MISSION® esiRNA - EHU011171 from Sigma-Aldrich
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MISSION® siRNA - SIHK0529 from Sigma-Aldrich
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MISSION® siRNA - SIHK0530 from Sigma-Aldrich
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MISSION® siRNA - SIHK0531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6656 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6656 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03612 from Sigma-Aldrich
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CSNK2A2 siRNA (Human) - CRH1029 from Cohesion Biosciences
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CSNK2A2 - MBS827027 from MyBioSource
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casein kinase IIα’ CRISPR/Cas9 KO Plasmid (h2) - sc-401148-KO-2 from Santa Cruz Biotechnology
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casein kinase IIα’ HDR Plasmid (h2) - sc-401148-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CSNK2A2 (NM_001896.2) - SHH270533 from Creative biogene
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shRNA set against Human CSNK2A2(NM_001896.2) - SHG204073 from Creative biogene
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