SPTLC1

Gene Symbol SPTLC1
Entrez Gene 10558
Alt Symbol HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI
Species Human
Gene Type protein-coding
Description serine palmitoyltransferase, long chain base subunit 1
Other Description LCB 1|SPT 1|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase 1|serine-palmitoyl-CoA transferase 1
Swissprots A8K681 O15269 Q96IX6 Q5VWB4
Accessions AAK29328 CCQ43355 EAW62804 EAW62805 EAW62806 O15269 AB209757 BAD92994 AF147304 AK098344 AK291546 BAF84235 AK299153 BAG61202 AK309775 BC007085 AAH07085 BC068537 AAH68537 DA305642 EC564300 Y08685 CAA69941 XM_011518138 XP_011516440 XM_011518139 XP_011516441 NM_001281303 NP_001268232 NM_006415 NP_006406 NM_178324 NP_847894
Function Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. {ECO:0000269|PubMed:19416851}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. Not detected in small intestine. {ECO:0000269|PubMed:17023427}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SPTLC1 CRISPR/Cas9 KO Plasmid (h) - sc-402829 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC1 HDR Plasmid (h) - sc-402829-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC1 Double Nickase Plasmid (h) - sc-402829-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC1 Double Nickase Plasmid (h2) - sc-402829-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC1 CRISPR Activation Plasmid (h) - sc-402829-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC1 CRISPR Activation Plasmid (h2) - sc-402829-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC1 Lentiviral Activation Particles (h) - sc-402829-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC1 Lentiviral Activation Particles (h2) - sc-402829-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC1 siRNA (h) - sc-106561 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPTLC1 shRNA Plasmid (h) - sc-106561-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPTLC1 shRNA (h) Lentiviral Particles - sc-106561-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU082241 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20545 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20545 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09507 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09507

SPTLC1 siRNA (Human) - CRH7179 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPTLC1 - MBS8238999 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPTLC1 (NM_006415.2) - SHH417536 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPTLC1(NM_178324.1) - SHL031512 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPTLC1(NM_006415.2) - SHL031530 from Creative biogene

Category siRNA
Species Reactivities Human

Human SPTLC1 siRNA - orb267681 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPTLC1 shRNA Plasmid (Human) - CHH7179 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPTLC1 miRNA 3'UTR clone - MiUTR1H-09889 from Creative biogene

Species Reactivities Human

SPTLC1 miRNA 3'UTR clone - MiUTR1H-09890 from Creative biogene

Species Reactivities Human
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