Gene Symbol | SPTLC1 |
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Entrez Gene | 10558 |
Alt Symbol | HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI |
Species | Human |
Gene Type | protein-coding |
Description | serine palmitoyltransferase, long chain base subunit 1 |
Other Description | LCB 1|SPT 1|long chain base biosynthesis protein 1|serine C-palmitoyltransferase|serine palmitoyltransferase 1|serine-palmitoyl-CoA transferase 1 |
Swissprots | A8K681 O15269 Q96IX6 Q5VWB4 |
Accessions | AAK29328 CCQ43355 EAW62804 EAW62805 EAW62806 O15269 AB209757 BAD92994 AF147304 AK098344 AK291546 BAF84235 AK299153 BAG61202 AK309775 BC007085 AAH07085 BC068537 AAH68537 DA305642 EC564300 Y08685 CAA69941 XM_011518138 XP_011516440 XM_011518139 XP_011516441 NM_001281303 NP_001268232 NM_006415 NP_006406 NM_178324 NP_847894 |
Function | Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. {ECO:0000269|PubMed:19416851}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed. Not detected in small intestine. {ECO:0000269|PubMed:17023427}. |
Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |
SPTLC1 CRISPR/Cas9 KO Plasmid (h) - sc-402829 from Santa Cruz Biotechnology
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SPTLC1 HDR Plasmid (h) - sc-402829-HDR from Santa Cruz Biotechnology
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SPTLC1 Double Nickase Plasmid (h) - sc-402829-NIC from Santa Cruz Biotechnology
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SPTLC1 Double Nickase Plasmid (h2) - sc-402829-NIC-2 from Santa Cruz Biotechnology
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SPTLC1 CRISPR Activation Plasmid (h) - sc-402829-ACT from Santa Cruz Biotechnology
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SPTLC1 CRISPR Activation Plasmid (h2) - sc-402829-ACT-2 from Santa Cruz Biotechnology
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SPTLC1 Lentiviral Activation Particles (h) - sc-402829-LAC from Santa Cruz Biotechnology
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SPTLC1 Lentiviral Activation Particles (h2) - sc-402829-LAC-2 from Santa Cruz Biotechnology
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SPTLC1 siRNA (h) - sc-106561 from Santa Cruz Biotechnology
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SPTLC1 shRNA Plasmid (h) - sc-106561-SH from Santa Cruz Biotechnology
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SPTLC1 shRNA (h) Lentiviral Particles - sc-106561-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU082241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20545 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20545 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09507 from Sigma-Aldrich
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SPTLC1 siRNA (Human) - CRH7179 from Cohesion Biosciences
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SPTLC1 - MBS8238999 from MyBioSource
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shRNA set against Human SPTLC1 (NM_006415.2) - SHH417536 from Creative biogene
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shRNA set against Human SPTLC1(NM_178324.1) - SHL031512 from Creative biogene
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shRNA set against Human SPTLC1(NM_006415.2) - SHL031530 from Creative biogene
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Human SPTLC1 siRNA - orb267681 from Biorbyt
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SPTLC1 shRNA Plasmid (Human) - CHH7179 from Cohesion Biosciences
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SPTLC1 miRNA 3'UTR clone - MiUTR1H-09889 from Creative biogene
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SPTLC1 miRNA 3'UTR clone - MiUTR1H-09890 from Creative biogene
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