IL6ST
| Gene Symbol | IL6ST |
|---|---|
| Entrez Gene | 3572 |
| Alt Symbol | CD130, CDW130, GP130, IL-6RB |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 6 signal transducer |
| Other Description | CD130 antigen|IL-6 receptor subunit beta|IL-6R subunit beta|gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form|gp130, oncostatin M receptor|interleukin receptor beta chain|interleukin-6 receptor subunit beta|membrane glycoprotein 130|membrane glycoprotein gp130|oncostatin-M receptor subunit alpha |
| Swissprots | Q9UQ41 Q5FC04 P40189 A0N0L4 |
| Accessions | ABK41905 EAW54936 EAW54937 EAW54938 P40189 AB015706 BAA78112 AB074172 AB102799 BAD89390 AB102800 BAD89391 AB102801 BAD89392 AB102802 BAD89393 AB102803 BAD89394 AB102804 BAD89395 AL049265 AW015107 BC071555 BC117402 AAI17403 BC117404 AAI17405 BC143842 BQ013034 DA863210 DA877322 HQ258523 ADR83277 HQ628629 AER93379 HQ628630 AER93380 M57230 AAA59155 S80479 AAB35921 U58146 AAB63010 XM_011543376 XP_011541678 XM_011543377 XP_011541679 NM_001190981 NP_001177910 NM_002184 NP_002175 NM_175767 NP_786943 NR_120480 |
| Function | Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events. {ECO:0000250}. |
| Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells. |
| Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Viral carcinogenesis, Signaling pathways regulating pluripotency of stem cells |
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