DIS3L2

Gene Symbol DIS3L2
Entrez Gene 129563
Alt Symbol FAM6A, PRLMNS, hDIS3L2
Species Human
Gene Type protein-coding
Description DIS3 like 3'-5' exoribonuclease 2
Other Description DIS3 mitotic control homolog-like 2|DIS3-like exonuclease 2|family with sequence similarity 6, member A
Swissprots Q69YG5 Q5XKH0 Q53S79 Q7Z4T6 Q6AW99 Q8IYB7 Q8N9K9 Q580W6
Accessions AAX82031 AAY24086 EAW70988 Q8IYB7 AA781347 AF443854 AAP97321 AK090419 BAC03400 AK094293 BAC04324 AK295363 BAG58327 AL834174 CAH10694 AW589919 BC026166 AAH26166 BC030113 BC036113 AAH36113 BG746662 BM128478 BX648325 CAH10545 DA058505 EU176261 ABW03712 EU176572 ABW03373 NM_001257281 NP_001244210 NM_001257282 NP_001244211 NM_152383 NP_689596 NR_046476 NR_046477
Function 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. {ECO:0000255|HAMAP-Rule:MF_03045, ECO:0000269|PubMed:23756462, ECO:0000269|PubMed:24141620}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:24141620}. Cytoplasm, P-body.

DIS3L2 (K-12) - sc-132270 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DIS3L2 (K-12): sc-132270. Western blot analysis of DIS3L2 expression in Jurkat (A) and I-11.15 (B) whole cell lysates and mouse lymph node tissue extract (C).

DIS3L2 (I-22) - sc-101939 from Santa Cruz Biotechnology

Host Rabbit
Clonality Polyclonal
DIS3L2 (I-22): sc-101939. Western blot analysis of DIS3L2 expression in Jurkat whole cell lysate.

Anti-DIS3L2 antibody - ab50848 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DIS3L2 antibody (ab50848) at 1.25 µg/mlLane 1 : MW markerLane 2 : Jurkat cell lysate at 10 µgSecondaryLane 2 : HRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-DIS3L2 antibody - ab169142 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-DIS3L2 antibody (ab169142) at 1/500 dilutionLane 1 : DIS3L2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysate Lysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-DIS3L2 antibody [6C7B2] - ab181743 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6C7B2
All lanes : Anti-DIS3L2 antibody [6C7B2] (ab181743) at 1/500 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysate

Anti-DIS3L2 Antibody (Internal) - LS-C155574 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Colon ca, using DIS3L2 antibody at 1:500 dilution.

Anti-DIS3L2 Antibody (aa27-250, clone 6C7B2) - LS-C285855 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6C7B2
IHC of paraffin-embedded endometrial cancer tissues using DIS3L2 mouse monoclonal antibody with DAB staining.

Anti-DIS3L2 Antibody (N-Terminus) - LS-C31330 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
DIS3L2 antibody LS-C31330 was used in IHC to stain formalin-fixed, paraffin-embedded human intestine.

Anti-DIS3L2 Antibody (aa121-170) - LS-C31331 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
DIS3L2 antibody LS-C31331 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.

DIS3L2 Antibody - NBP1-84740 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

DIS3L2 Antibody (6C7B2) - NBP2-37316 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6C7B2

DIS3L2 Antibody - NBP1-80480 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DIS3L2 Antibody [NBP1-80480] - Titration: 1.25ug/ml Positive Control: Human Muscle.

DIS3L2 Antibody - NBP1-80479 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DIS3L2 Antibody [NBP1-80479] - Titration: 1.25ug/ml, Positive Control: Jurkat cell lysate.

DIS3L2 Antibody - NBP2-38264 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DIS3L2 Antibody [NBP2-38264] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG

DIS3L2 Antibody - NBP2-16166 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DIS3L2 Antibody [NBP2-16166] - Sample (30 ug of whole cell lysate) A: NT2D1 B: IMR32 C: U87-MG 7. 5% SDS PAGE gel, diluted at 1:3000.

DIS3L2 Antibody - H00129563-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot analysis of MGC42174 expression in transfected 293T cell line by MGC42174 MaxPab polyclonal antibody (B01). Lane 1: MGC42174 transfected lysate (69.10 KDa). Lane 2: Non-transfected lysate.

DIS3L2 Polyclonal Antibody - bs-9053R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MGC42174 (AB2) antibody produced in rabbit - AV41146 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MGC42174 (ab2): <B>Cat. No. AV41146</B>: Immunohistochemistry of MGC42174 in Human Intestine tissue with MGC42174 antibody at 4-8 μg/mL.

Anti-MGC42174 (AB1) antibody produced in rabbit - AV41145 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MGC42174 (ab1): <B>Cat. No. AV41145</B>: Immunohistochemistry of MGC42174 in Human Heart tissue with MGC42174 antibody at 4-8 μg/mL.

MGC42174 antibody - N-terminal region (ARP41145_T100) - ARP41145_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MGC42174 antibody - N-terminal region (ARP41146_T100) - ARP41146_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PRKACA-Antibody - AO1946a from Abgent, a WuXi AppTec company

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 7H3A4
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

DIS3L2 antibody [N2C1], Internal - GTX118786 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-DIS3L2 antibody [N2C1], Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX118786

DIS3L2 antibody, N-term - GTX47207 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-DIS3L2 antibody, N-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX47207

DIS3L2 antibody, N-term - GTX47208 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Anti-DIS3L2 antibody, N-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX47208
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