MUC2

Gene Symbol MUC2
Entrez Gene 4583
Alt Symbol MLP, MUC-2, SMUC
Species Human
Gene Type protein-coding
Description mucin 2, oligomeric mucus/gel-forming
Other Description intestinal mucin-2|mucin 2, intestinal/tracheal|mucin-2|mucin-like protein
Swissprots Q14878 Q02817
Accessions AAA59875 AAC51519 AAG18515 AAG18516 EAX02421 EAX02422 Q02817 AA527400 AF257167 AAG18517 AW054915 BG982960 BQ340542 CV354692 DV080627 L21998 AAB95295 M22404 AAA36333 M22405 AAA36334 M57417 AAA63229 M86523 AAA59861 M94131 AAA59163 M94132 AAA59164 NM_002457 NP_002448
Function Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer. {ECO:0000269|PubMed:19432394}.
Subcellular Location Secreted. Note=In the intestine, secreted into the inner and outer mucus layers. {ECO:0000250}.
Tissue Specificity Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
Top Pathways Vibrio cholerae infection, Amoebiasis

Mucin 2 (B306.1) - sc-59859 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Mucin 2 (K-15) - sc-23171 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mucin 2 (K-15): sc-23171. Immunofluorescence staining of methanol-fixed SW480 cells showing cytoplasmic and cell surface localization.

Mucin 2 (994/152) - sc-59956 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Mucin 2 (H-300) - sc-15334 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mucin 2 (H-300): sc-15334. Immunoperoxidase staining of formalin fixed, paraffin-embedded human colon tissue showing cytoplasmic and extracellular staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Mucin 2 (P-18) - sc-23170 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mucin 2 (P-18): sc-23170. Immunofluorescence staining of methanol-fixed SW480 cells showing cytoplasmic and cell surface localization.

Mucin 2 (R-12) - sc-13312 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mucin 2 (R-12): sc-13312. Western blot analysis of Mucin 2 expression in HeLa whole cell lysate.

Anti-MUC2 antibody - ab76774 from Abcam

Prices $382.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
ab76774 at 1/100 dilution, staining MUC2 in human colon cancer tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections). The DAB staining procedure was used with hematoxylin as counterstain.

Anti-MUC2 antibody - ab90007 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of MUC2 staining in human normal colon FFPE section, performed on a BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab90007, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX

Anti-MUC2 antibody - ab37443 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-MUC2 antibody - ab97386 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MUC2 antibody (ab97386) at 1/3000 dilution + Raji whole cell lysate at 30 µg

Anti-MUC2 antibody [994/152] - ab22712 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 994/152

Anti-MUC2 antibody [996/1] - ab11197 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 996/1

Anti-MUC2 antibody [B306.1] - ab7848 from Abcam

Prices $378.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone B306.1
Ab7848 staining human normal colon. Staining is localised to the membrane.Left panel: with primary antibody diluted 1:4000. Right panel: isotype control.Sections were stained using an automated system DAKO Autostainer Plus , at room temperature. Sections were rehydrated and antigen retrieved with the Dako 3-in-1 AR buffer EDTA pH 9.0 in a DAKO PT Link. Slides were peroxidase blocked in 3% H2O2 in methanol for 10 minutes. They were then blocked with Dako Protein block for 10 minutes (containing casein 0.25% in PBS), then incubated with primary antibody for 20 minutes, and detected with Dako Envision Flex amplification kit for 30 minutes. Colorimetric detection was completed with diaminobenzidine for 5 minutes. Slides were counterstained with Haematoxylin and coverslipped under DePeX. Please note that for manual staining we recommend to optimize the primary antibody concentration and incubation time (overnight incubation), and amplification may be required.

Anti-MUC2 antibody [Ccp58] - ab118964 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone Ccp58
ab118964 at 1/100 staining MUC2 in Formalin-fixed, Paraffin-embedded Human colon tissue by Immunohistochemistry.

Anti-MUC2 antibody [Ccp58] - ab49460 from Abcam

Prices $376.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone Ccp58
ICC/IF image of ab49460 stained Hek293 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab49460, 1/1000 dilution) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-mouse IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-MUC2 antibody [EPR6144] - ab133555 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6144
Anti-MUC2 antibody [EPR6144] (ab133555) at 1/1000 dilution + Human small intestine lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-MUC2 antibody [EPR6145] - ab134119 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6145
Immunohistochemical analysis of paraffin embedded Human colon tissue labelling MUC2 with ab134119 at 1/250.

Anti-MUC2 antibody, prediluted - ab76775 from Abcam

Prices $370.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal

Anti-MUC2 antibody [SPM513], prediluted - ab52130 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM513
ab52130, ready to use for staining human MUC2 in small intestine tissue by Immunohistochemistry, Formalin fixed Paraffin embedded tissue.

Anti-Mucin 2 / MUC2 Antibody (clone SPM512) IHC-plus™ - LS-B3372 from LifeSpan Bioscience

Prices $395.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone SPM512
Anti-MUC2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3372 concentration 10 ug/ml.

Anti-Mucin 2 / MUC2 Antibody - LS-C16653 from LifeSpan Bioscience

Prices $495.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal

Anti-Mucin 2 / MUC2 Antibody - LS-C72884 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-Mucin 2 / MUC2 Antibody (clone Ccp58) - LS-C85310 from LifeSpan Bioscience

Prices $650.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone Ccp58

Anti-Mucin 2 / MUC2 Antibody (clone 996/1) - LS-C87832 from LifeSpan Bioscience

Prices $295.00, $620.00, $1,015.00
Sizes 20 µg, 100 µg, 1 ml
Host Mouse
Clonality Monoclonal
Clone 996/1

Anti-Mucin 2 / MUC2 Antibody (FITC) - LS-C89547 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
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