AXL

Gene Symbol AXL
Entrez Gene 558
Alt Symbol ARK, JTK11, Tyro7, UFO
Species Human
Gene Type protein-coding
Description AXL receptor tyrosine kinase
Other Description AXL oncogene|AXL transforming sequence/gene|tyrosine-protein kinase receptor UFO
Swissprots P30530 Q9UD27 Q8N5L2
Accessions CAA46829 CBX54237 CBX54238 EAW57022 EAW57023 P30530 AA021223 AI300772 AI309979 AK309139 AK310881 AL556721 BC032229 AAH32229 CA437238 DA478638 DQ894117 ABM85043 HY045208 M76125 AAA61243 S65125 AAB20305 X57019 CAA40338 X66029 NM_001278599 NP_001265528 NM_001699 NP_001690 NM_021913 NP_068713
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3- kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron sur
Subcellular Location Cell membrane {ECO:0000269|PubMed:7896447}; Single-pass type I membrane protein {ECO:0000269|PubMed:7896447}.
Tissue Specificity Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. {ECO:0000269|PubMed:7896447}.

Phospho-Axl (Tyr702) (D12B2) Rabbit mAb - 5724 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D12B2
Western blot analysis of extracts from NCI-H1299 cells, untreated or Gas6-treated (100 ng/ml for 10 minutes), using Phospho-Axl (Tyr702) (D12B2) Rabbit mAb (upper) or Axl (C44G1) Rabbit mAb #4566 (lower).

Axl (C89E7) Rabbit mAb - 8661 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C89E7
Western blot analysis of extracts from various cell lines using Axl (C89E7) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Axl (C44G1) Rabbit mAb - 4566 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C44G1
Western blot analysis of extracts from human skeletal muscle cells (hSkMC), PAE and HUVEC cells using Axl (C44G1) Rabbit mAb.

Axl (L283) Antibody - 3269 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from COS and HeLa cells using Axl (L283) Antibody.

Axl (C2B12) Rabbit mAb - 4939 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C2B12
Western blot analysis of cell extracts from various cell lines, using Axl (C2B12) Rabbit mAb.

Axl Antibody - 4977 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines, using Axl Antibody.

Axl (C-20) - sc-1096 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Axl expression in FHs 173We (A,E), CCD-1064Sk (B,F), NIH/3T3 (C,G) and 3611-RF (D,H) whole cell lysates. Antibodies tested include Axl (C-20): sc-1096 (AD) and Axl (M-20): sc-1097 (EH).

Axl (B-2) - sc-166268 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Axl (B-2): sc-166268. Western blot analysis of Axl expression in non-transfected: sc-117752 (A) and human Axl transfected: sc-114191 (B) 293T whole cell lysates.

Axl (H-124) - sc-20741 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Axl (H-124): sc-20741. Western blot analysis of Axl expression in non-transfected: sc-117752 (A) and human Axl transfected: sc-114191 (B) 293T whole cell lysates.

Axl (H-3) - sc-166269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Axl (H-3): sc-166269. Western blot analysis of Axl expression in non-transfected: sc-117752 (A) and human Axl transfected: sc-114191 (B) 293T whole cell lysates.

Axl (M-20) - sc-1097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of Axl expression in FHs 173We (A,E), CCD-1064Sk (B,F), NIH/3T3 (C,G) and 3611-RF (D,H) whole cell lysates. Antibodies tested include Axl (C-20): sc-1096 (AD) and Axl (M-20): sc-1097 (EH).

Anti-Axl antibody - ab37861 from Abcam

Prices $391.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Axl antibody (ab37861) + SKBR3 cell lysateSecondaryHRP-conjugated anti-rabbit IgGdeveloped using the ECL techniqueObserved band size : 97 kDa (why is the actual band size different from the predicted?)Additional bands at : 25 kDa. We are unsure as to the identity of these extra bands.

Anti-Axl antibody - ab135664 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Axl antibody (ab135664) at 1/50 dilution + A375 cell line lysate at 35 µg

Anti-Axl antibody - ab54803 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Axl antibody - ab32828 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Axl antibody - ab77773 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Axl antibody (ab77773) at 1 µg/mlLane 1 : Heart (Human) Tissue Lysate - adult normal tissue (ab29431)Lane 2 : Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330)Lane 3 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 4 : Brain (Human) Tissue Lysate - adult normal tissue (ab29466)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Axl antibody - ab123597 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Axl antibody (ab123597) at 1/100 dilution + K562 cell line lysate at 35 µg

Anti-Axl antibody - ab72084 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Axl antibody (ab72084) at 0.5 µg/mlLane 1 : HUVEC cell lysateLane 2 : HUVEC cell lysate plus immunizing peptide

Anti-Axl antibody [7E10] - ab130218 from Abcam

Host Mouse
Clonality Monoclonal
Clone 7E10
ab130218 at 1/200 dilution, staining Axl in methanol-fixed HEK293 cells trasfected with Axl-hIgGFc by Confocal immunofluorescence (green). Blue: DRAQ5 fluorescent DNA dye.

Anti-Axl antibody [MM0098-2N33] - ab89224 from Abcam

Prices $388.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0098-2N33
ab89224 used in Flow Cytometry.Cells were trypsinized for 1 minute at room temperature and wahed once in cold PBS. They were stained with ab89224 diluted 1/200 in 5% BSA/PBS for 45 minutes on ice, washed and incbuated with ab98794 at a 1/200 dilution. Cells were filtered and read in a FACScan using the FL1 sensor.

Anti-Axl antibody - C-terminal - ab72069 from Abcam

Prices $388.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Axl antibody - C-terminal (ab72069) at 1/100 dilution + SKBR3 cell lysate at 12.5 µgSecondaryHRP-anti-rabbit

Anti-AXL Antibody (C-Terminus) IHC-plus™ - LS-B12012 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-AXL Antibody (N-Terminus) - LS-C136999 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-AXL Antibody (Extracellular Domain) - LS-C125141 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-AXL Antibody (aa785-801) - LS-C148882 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
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