TNFRSF10A
| Gene Symbol | TNFRSF10A |
|---|---|
| Entrez Gene | 8797 |
| Alt Symbol | APO2, CD261, DR4, TRAILR-1, TRAILR1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | tumor necrosis factor receptor superfamily, member 10a |
| Other Description | TNF-related apoptosis-inducing ligand receptor 1|TRAIL receptor 1|TRAIL-R1|cytotoxic TRAIL receptor|death receptor 4|tumor necrosis factor receptor superfamily member 10A|tumor necrosis factor receptor superfamily member 10a variant 2 |
| Swissprots | O00220 Q96E62 A8K5I4 Q53Y72 |
| Accessions | ABK41896 CCA94571 CCQ43238 EAW63636 O00220 AK291299 BAF83988 BC012866 AAH12866 BT006906 AAP35552 CN423254 DB101031 DQ891791 ABM82717 DQ894973 ABM85899 FJ795027 ACO37639 JF729355 AEB77762 U90875 AAC51226 NM_003844 NP_003835 |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. {ECO:0000269|PubMed:9430227}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. |
| Top Pathways | Cytokine-cytokine receptor interaction, Apoptosis, Natural killer cell mediated cytotoxicity, Measles, Influenza A |
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