ACTN2

Gene Symbol	ACTN2
Entrez Gene	88
Alt Symbol	CMD1AA
Species	Human
Gene Type	protein-coding
Description	actinin, alpha 2
Other Description	F-actin cross-linking protein\|alpha-actinin skeletal muscle\|alpha-actinin-2
Swissprots	B1ANE4 P35609 Q86TF4 B2RCS5 Q86TI8
Accessions	AAA51584 CAB61269 EAW70064 EAW70065 P35609 AB209521 BAD92758 AK294906 BAH11921 AK297469 BAH12587 AK297618 BAH12632 AK297628 BAH12634 AK297886 BAH12687 AK315250 BAG37672 BC047901 AAH47901 BC051770 AAH51770 BX103017 CB153006 DC378038 M86406 AAA51583 NM_001103 NP_001094 NM_001278343 NP_001265272 NM_001278344 NP_001265273
Function	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
Subcellular Location	Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269\|PubMed:11171996, ECO:0000269\|PubMed:19932097}. Note=Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
Tissue Specificity	Expressed in both skeletal and cardiac muscle.
Top Pathways	Systemic lupus erythematosus, Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Leukocyte transendothelial migration, Amoebiasis

α-actinin-2 (A-25) - sc-130928 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

α-actinin-2 (A-25): sc-130928. Western blot analysis of α-actinin-2 expression in human fetal heart tissue extract.

Anti-Sarcomeric Alpha Actinin antibody - ab72592 from Abcam

Prices	$390.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Sarcomeric Alpha Actinin antibody (ab72592) at 1/500 dilutionLane 1 : Extracts from HeLa cellsLane 2 : Extracts from HepG2 cellsLane 3 : Extracts from HUVEC cellsLane 4 : Extracts from HUVEC cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Sarcomeric Alpha Actinin antibody - ab113086 from Abcam

Prices	$384.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

ab113086 at 10 &microg/ml staining Sarcomeric Alpha Actinin in Formalin-fixed, Paraffin-embedded Human Heart tissue by Immunohistochemistry.

Anti-Sarcomeric Alpha Actinin antibody [EP2529Y] - ab68167 from Abcam

Prices	$99.00, $385.00
Sizes	10 µl, 100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2529Y

All lanes : Anti-Sarcomeric Alpha Actinin antibody [EP2529Y] (ab68167) at 1/20000 dilutionLane 1 : Human skeletal muscle lysateLane 2 : Rat heart lysateLane 3 : Human heart lysateLysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-Sarcomeric Alpha Actinin antibody [EP2530Y] - ab68168 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2530Y

Anti-Sarcomeric Alpha Actinin antibody [EP2530Y] (ab68168) at 1/50000 dilution + human skeletal muscle lysate at 10 µgSecondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-Sarcomeric Alpha Actinin antibody [SA-20] - ab66186 from Abcam

Prices	$379.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	SA-20

Overlay histogram showing HeLa cells stained with ab66186 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab66186, 1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was a goat anti-mouse Alexa Fluor® 488 (IgG; H&L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-ACTN2 Antibody (aa586-635) - LS-C31450 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (clone EA-53) - LS-C95446 from LifeSpan Bioscience

Prices	$320.00, $435.00
Sizes	500 µl, 1 ml
Host	Mouse
Clonality	Monoclonal
Clone	EA-53

Anti-ACTN2 Antibody (aa751-779, AP) - LS-C250767 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (aa751-779, Biotin) - LS-C250769 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (aa751-779, APC) - LS-C250768 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (C-Terminus) - LS-C40329 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

ACTN2 antibody LS-C40329 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.

Anti-ACTN2 Antibody (clone 5C5) - LS-C95373 from LifeSpan Bioscience

Prices	$335.00, $475.00
Sizes	500 µl, 1 ml
Host	Mouse
Clonality	Monoclonal
Clone	5C5

Formalin-fixed, paraffin-embedded human skeletal muscle stained with Actin, Sarcomeric antibody LS-C95373.

Anti-ACTN2 Antibody (aa751-779, FITC) - LS-C250770 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (aa1-254) - LS-C292610 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (aa751-779, PE) - LS-C250772 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (aa1-254, FITC) - LS-C301715 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (aa1-254, Biotin) - LS-C298543 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (clone SA-20) - LS-C312478 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	SA-20

Anti-ACTN2 Antibody (aa751-779, Azide-free, HRP) - LS-C250771 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (aa750-779) - LS-C319313 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-ACTN2 Antibody (aa751-779) - LS-C156006 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

ACTN2 Antibody western blot of mouse heart tissue lysates (35 ug/lane). The ACTN2 antibody detected the ACTN2 protein (arrow).

Anti-ACTN2 Antibody (N-Terminus, clone EP2529Y) - LS-C105281 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2529Y

IHC of paraffin-embedded human muscles using anti-Alpha-Actinin 2 antibody (LS-C105281).

Anti-ACTN2 Antibody (C-Terminus, clone EP2530Y) - LS-C105310 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2530Y

IHC of paraffin-embedded human muscles using anti-Actinin 2 antibody (LS-C105310).

Anti-ACTN2 Antibody - LS-C332732 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of HeLa cell line, using ACTN2 antibody.

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