| Gene Symbol |
CIITA
|
| Entrez Gene |
4261
|
| Alt Symbol |
C2TA, CIITAIV, MHC2TA, NLRA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
class II, major histocompatibility complex, transactivator
|
| Other Description |
MHC class II transactivator|MHC class II transactivator type III|NLR family, acid domain containing|nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
|
| Swissprots |
Q96KL4 P33076 Q8SNB8 D3DUG0 A0N0N9 E9PFE0 Q29675
|
| Accessions |
AAB92363 AAC39714 ABK41930 CDL97011 EAW85168 EAW85169 EAW85170 EAW85171 EAW85172 EAW85173 EAW85174 P33076 AF410154 AAL04118 AY084054 AAM15723 AY084055 AAM15724 AY699071 AAU06586 BC172348 AAI72348 BE247223 BM193016 HG507727 U18259 AAA88861 U18288 AAA88862 U31931 AAA92364 X74301 CAA52354 XM_006720880 XP_006720943 XM_011522484 XP_011520786 XM_011522485 XP_011520787 XM_011522486 XP_011520788 XM_011522487 XP_011520789 XM_011522488 XP_011520790 XM_011522489 XP_011520791 XM_011522490 XP_011520792 XM_011522491 XP_011520793 XM_011522492 XP_011520794 XM_011522493 XP_011520795 XM_011522494 XP_011520796 XM_011522495 XP_011520797 XM_011522496 XP_011520798 XR_932841 XR_932842 XR_932843 XR_932846 XR_932847 XR_932848 NM_000246 NP_000237 NM_001286402 NP_001273331 NM_001286403 NP_001273332 NR_104444
|
| Function |
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). {EC
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:23007646}. Nucleus, PML body {ECO:0000269|PubMed:23007646}. Note=Recruited to PML body by PML.
|
| Top Pathways |
Primary immunodeficiency, Toxoplasmosis, Influenza A, Tuberculosis, Antigen processing and presentation
|
